{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:40:13Z","timestamp":1765039213887},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T00:00:00Z","timestamp":1385337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Medium\u2010 and long\u2010term survival is low in esophageal cancer (EC) patients, which is thought to be due to tumor characteristics. Our aim was to determine both tumor\u2010 and non\u2010tumor\u2010related characteristics affecting survival in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with primary EC between 1990 and 2008 in the southern part of the Netherlands were identified. Multivariable logistic regression was used to identify determinants of survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 703 patients with EC were included for the 1\u2010year, 551 for the 3\u2010year and 436 for the 5\u2010year survival analysis. Poor 1\u2010year survival was independently associated with chemoradiation (compared to surgery), positive lymph nodes (N1\u2010stage) and 1 or \u22652 comorbidities. Adenocarcinoma (EAC) compared to squamous cell carcinoma was significantly associated with a better 1\u2010year survival. Poor 3\u2010 and 5\u2010year survival was associated with N1\u2010stage and chemoradiation. Positive prognostic factors for 3\u2010 and 5\u2010year survival were neoadjuvant therapy and female gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both tumor\u2010related (negative lymph nodes and EAC histology) and non\u2010tumor\u2010related factors (surgery, neoadjuvant therapy, and female gender) are associated with a better survival of EC. Although it is not clear how histology and gender affect EC survival, knowledge of these factors may be relevant for clinical decision making. <jats:italic>J. Surg. Oncol. 2014 109:465\u2013471<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23513","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T15:48:35Z","timestamp":1385394515000},"page":"465-471","source":"Crossref","is-referenced-by-count":21,"title":["Prognostic factors for medium\u2010 and long\u2010term survival of esophageal cancer patients in the Netherlands"],"prefix":"10.1002","volume":"109","author":[{"given":"Pauline","family":"Bus","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valery E.","family":"Lemmens","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center South (CCCS) Eindhoven The Netherlands"},{"name":"Department of Public Health Erasmus Medical Center Rotterdam The 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