{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:44:00Z","timestamp":1781739840377,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T00:00:00Z","timestamp":1385596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Nature Science Foundation of China","award":["81101591"],"award-info":[{"award-number":["81101591"]}]},{"name":"Natural Science Foundation of Guangdong Province, China","award":["S2011040005278"],"award-info":[{"award-number":["S2011040005278"]}]},{"name":"Natural Science Foundation of Guangdong Province, China","award":["9151008901000157"],"award-info":[{"award-number":["9151008901000157"]}]},{"name":"Science and Technology Planning Project of Guangdong Province, China","award":["2010B060900043"],"award-info":[{"award-number":["2010B060900043"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Systemic failure remains a predominant issue in locally advanced rectal cancer (LARC). A new strategy using capecitabine and oxaliplatin (XELOX regimen) administered prior to and then concomitant to radiotherapy for high risk LARC is developed in our practice. The aim of the present study was to evaluate the short\u2010term efficacy and toxicities of this strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were treated with one cycle XELOX regimen (oxaliplatin 130\u2009mg\/m<jats:sup>2<\/jats:sup> on day 1 with capecitabine 1,000\u2009mg\/m<jats:sup>2<\/jats:sup> twice daily for 14 days every 3 weeks), followed by chemoradiation (50\u2009Gy over 5 weeks) with modified XELOX regimen (oxaliplatin dose reduction to 100\u2009mg\/m<jats:sup>2<\/jats:sup>), and total mesorectal excision. Tumor response, toxicities, and surgical complications were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two patients treated with the strategy were identified. All patients completed planned dose of induction chemotherapy and concurrent chemoradiotherapy. Grade 3 toxicities were thrombocytopenia (4.8%), diarrhea (7.1%), proctitis (4.8%), and radiation dermatitis (7.1%). Five patients (12.5%) developed postoperative complications. Pathologic complete response (pCR) and nearly pCR were achieved in 7 (15.0%) and 13 patients (35.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The preliminary results suggest that induction chemotherapy followed by chemoradiotherapy with capecitabine and oxaliplatin in LARC is well tolerated. The strategy achieves favorable short term outcome in terms of pCR and nearly pCR rate, which warrants further investigation. <jats:italic>J. Surg. Oncol. 2014 109:478\u2013482<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23516","type":"journal-article","created":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T03:28:39Z","timestamp":1385695719000},"page":"478-482","source":"Crossref","is-referenced-by-count":19,"title":["Evaluation of capecitabine and oxaliplatin administered prior to and then concomitant to radiotherapy in high risk locally advanced rectal cancer"],"prefix":"10.1002","volume":"109","author":[{"given":"Yuan\u2010Hong","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou P.R. China"},{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"An","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou P.R. China"},{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Jiang","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou P.R. China"},{"name":"Department of Pathology Sun Yat\u2010sen University Cancer Center Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou P.R. China"},{"name":"Department of General Surgery Affiliated Chaozhou Central Hospital of Southern Medical University Chaozhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu\u2010Yan","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou P.R. China"},{"name":"Department of Colorectal Surgery Sun Yat\u2010sen University Cancer Center Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Heng","family":"Kong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou P.R. China"},{"name":"Department of General Surgery Affiliated Chaozhou Central Hospital of Southern Medical University Chaozhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Zhong","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou P.R. China"},{"name":"Department of General Surgery Affiliated Chaozhou Central Hospital of Southern Medical University Chaozhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou P.R. China"},{"name":"Department of General Surgery Affiliated Chaozhou Central Hospital of Southern Medical University Chaozhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Hua","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou P.R. China"},{"name":"Department of General Surgery Affiliated Chaozhou Central Hospital of Southern Medical University Chaozhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou P.R. China"},{"name":"Department of General Surgery Affiliated Chaozhou Central Hospital of Southern Medical University Chaozhou P.R. 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