{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:04:05Z","timestamp":1777003445436,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T00:00:00Z","timestamp":1387843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National health research institute, Taiwan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To report the results of a phase II trial combining celecoxib and preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Patients with clinical stage II or III rectal cancer were treated with radiotherapy of 44\u2009Gy in 22 fractions. Concurrent chemotherapy consisted of oral tegafur\u2010uracil and folinate on days 1\u201330 and 38\u201365. Celecoxib (400\u2009mg\/day) given from days 1 to 65. Surgery was done on day 70. The expression of cyclooxygenase 2 (COX\u20102) in tumor tissues was evaluated microscopically as a prognostic factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2008 to 2011, 53 patients completed CRT+ celecoxib therapy and 47 received radical surgery. Grade 3 diarrhea developed in 5 (9%). Grade 4 anemia was seen in 2 (4%). Pathological complete response (pCR) was seen in 6 (13%). T or N downstaging found in 38 (81%). Sphincter preservation was achieved in 77% of low\u2010positioned tumors. Patients with tumors expressing high\u2010level COX\u20102 after CRT\u2009+\u2009celecoxib treatment had inferior pelvic control (<jats:italic>P<\/jats:italic>\u2009=\u20090.01), disease\u2010free survival (<jats:italic>P<\/jats:italic>\u2009=\u20090.04), and overall survival (<jats:italic>P<\/jats:italic>\u2009=\u20090.03) than those with low\u2010level expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Celecoxib can be safely combined with preoperative CRT for rectal cancer. More intensified adjuvant therapy may be considered for tumors expressing high\u2010level COX\u20102 after CRT and surgery. <jats:italic>J. Surg. Oncol. 2014 109:580\u2013585<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23538","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T11:07:26Z","timestamp":1387883246000},"page":"580-585","source":"Crossref","is-referenced-by-count":23,"title":["Celecoxib plus chemoradiotherapy for locally advanced rectal cancer: A phase II TCOG study"],"prefix":"10.1002","volume":"109","author":[{"given":"Ling\u2010Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Cancer Center Taipei Veterans General Hospital &amp; School of Medicine National Yang Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin\u2010Fu","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics National Health Research Institute Miaoli Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William 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