{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:03:51Z","timestamp":1762506231325},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T00:00:00Z","timestamp":1388102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Preoperative chemoradiotherapy (CRT) significantly decreases local recurrence in advanced rectal cancer. We studied whether the degree of tumor shrinkage can be used as a predictor of histologic response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects were 114 patients with locally advanced rectal cancer who underwent total mesorectal excision after receiving radiotherapy combined with uracil\/tegafur (UFT) or S\u20101. The degree of tumor shrinkage based on barium enema examination and magnetic resonance imaging (MRI) were assessed before CRT and immediately before surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A histologic complete response (ypCR), histologic marked regression, T and N downstaging were associated with significantly higher tumor\u2010shrinkage rates on barium enema (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, respectively) as well as on MRI (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, and <jats:italic>P<\/jats:italic>\u2009=\u20090.01, respectively). On multivariate analysis, ypCR and histologic marked regression were significantly related only to tumor\u2010shrinkage rates on barium enema (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01 and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, respectively), and were not related to tumor\u2010shrinkage rates on MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The degree of tumor shrinkage is closely related to the final histologic response. Two\u2010dimensionally evaluated tumor\u2010shrinkage rates based on barium enema are adequate for the prediction of histologic response. <jats:italic>J. Surg. Oncol 2014; 109:659\u2013664<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23550","type":"journal-article","created":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T14:24:41Z","timestamp":1388154281000},"page":"659-664","source":"Crossref","is-referenced-by-count":13,"title":["Relationship between histologic response and the degree of tumor shrinkage after chemoradiotherapy in patients with locally advanced rectal cancer"],"prefix":"10.1002","volume":"109","author":[{"given":"Toshiyuki","family":"Suzuki","sequence":"first","affiliation":[{"name":"Departments of Surgery Tokai University School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sotaro","family":"Sadahiro","sequence":"additional","affiliation":[{"name":"Departments of Surgery Tokai University School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Departments of Surgery Tokai University School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutake","family":"Okada","sequence":"additional","affiliation":[{"name":"Departments of Surgery Tokai University School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gota","family":"Saito","sequence":"additional","affiliation":[{"name":"Departments of Surgery Tokai University School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akemi","family":"Kamijo","sequence":"additional","affiliation":[{"name":"Departments of Surgery Tokai University School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Akiba","sequence":"additional","affiliation":[{"name":"Department of Radiology Tokai University School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Kawada","sequence":"additional","affiliation":[{"name":"Department of Radiology Tokai University School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060829"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.7629"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000257358.56863.ce"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040694"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70172-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00732-X"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0924-4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00345-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.09.031"},{"key":"e_1_2_9_11_1","unstructured":"JSCCR: \u201cJapanese Society for Cancer of the Colon and Rectum. 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