{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:12:54Z","timestamp":1792026774985,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The main tenets of local excision of rectal cancer following neoadjuvant chemoradiation (CRT) are that the mucosal scar represents the main focus of residual disease and a solid conglomerate around this rather than being scattered (fragmented) through the bowel wall.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of a prospective cohort of patients with residual rectal ycT1\u20102N0 adenocarcinoma with small residual tumors (\u22643\u2009cm) following CRT who underwent transanal endoscopic microsurgery (TEM) with 1\u2010cm margins around the residual mucosal abnormality was performed. Distribution and morphology (solid vs. fragmented) of tumor spread were studied and correlated to postoperative oncological outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients were included. Twenty percent (n\u2009=\u20096) were ypT1, 60% (n\u2009=\u200918) were ypT2, and 20% (n\u2009=\u20096) were ypT3 tumors. Fragmentation was present in 37%. The mean distance between foci of residual scattered tumor was 3.6\u2009\u00b1\u20092.0\u2009mm. Lateral spread under normal mucosa was present in 19 specimens (53%; mean extension 4.8\u2009\u00b1\u20092.4\u2009mm). With a median follow up of 32 months, none of these findings impacted upon development of recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both occult lateral spread and fragmented tumor patterns are common findings after CRT. Despite the potential of occult spread to mislead surgeon choice of resection margin, its presence did not influence oncological outcome in this series. <jats:italic>J. Surg. Oncol. 2014 109:853\u2013858<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23571","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T11:43:15Z","timestamp":1392205395000},"page":"853-858","source":"Crossref","is-referenced-by-count":49,"title":["Fragmented pattern of tumor regression and lateral intramural spread may influence margin appropriateness after TEM for rectal cancer following neoadjuvant CRT"],"prefix":"10.1002","volume":"109","author":[{"given":"Rodrigo O.","family":"Perez","sequence":"first","affiliation":[{"name":"Angelita &amp; Joaquim Gama Institute S\u00e3o Paulo Brazil"},{"name":"Colorectal Surgery Division University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"},{"name":"Ludwig Institute for Cancer Research S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelita","family":"Habr\u2010Gama","sequence":"additional","affiliation":[{"name":"Angelita &amp; 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