{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:57:49Z","timestamp":1788872269134,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"crossref","award":["03-2012-190"],"award-info":[{"award-number":["03-2012-190"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastric adenocarcinoma is the sixth most common and third most lethal cancer in the world. Except for HER2\u2010targeted therapy, targeted agents against specific molecules participating in gastric carcinogenesis, including those in the mechanistic target of rapamycin (serine\/threonine kinase) (mTOR) pathway have not been proved to be effective. However, some studies have suggested that dysfunction of TSC1 may augment mTOR inhibitor activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied p\u2010mTOR and TSC1 status by immunohistochemical analysis of gastric carcinoma samples using a tissue microarray method and expression values adopted from The Cancer Genome Atlas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High p\u2010mTOR and low TSC1 expression status is associated with adverse clinicopathologic parameters. Patients with high p\u2010mTOR levels showed poor survival. Patients with low TSC1 levels showed unfavorable survival status in the overall patients group. The combination of p\u2010mTOR status and TSC1 status provided more strong survival information than using each parameter alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In gastric cancer, high p\u2010mTOR expression level is a statistically significant parameter in multivariate and Kaplan\u2013Meier analyses (log\u2010rank test). In addition to p\u2010mTOR, TSC1 expression provided additional information to predict survival. We therefore suggest that evaluation of both p\u2010mTOR and TSC1 status may be helpful in clinical trials related to mTOR inhibitors.\n                      <jats:italic>J. Surg. Oncol. 2014 109:812\u2013817<\/jats:italic>\n                      . \u00a9 2014 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.23585","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T05:36:43Z","timestamp":1393393003000},"page":"812-817","source":"Crossref","is-referenced-by-count":22,"title":["Prognostic implication of TSC1 and mTOR expression in gastric carcinoma"],"prefix":"10.1002","volume":"109","author":[{"given":"Sun\u2010ju","family":"Byeon","sequence":"first","affiliation":[{"name":"Department of Pathology Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoung","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min A","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_6_3_1","first-page":"48","volume-title":"WHO Classification of Tumours of the Digestive System (IARC WHO Classification of Tumours).\u201d","author":"Lauwer GY","year":"2010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61873-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61121-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3025"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.170"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.7.9.6416"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24872"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2013.61.3.117"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.3552"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1226344"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001671"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20080281"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.237"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2138"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604915"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.452"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4176"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3185"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176344552"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.23585","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.23585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T19:18:09Z","timestamp":1696447089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.23585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,26]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1002\/jso.23585"],"URL":"https:\/\/doi.org\/10.1002\/jso.23585","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,26]]}}}