{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:12:14Z","timestamp":1768583534982,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T00:00:00Z","timestamp":1394582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary metastasectomy of renal cell carcinomas (RCC) remains controversial. Thoracic lymph node involvement (LNI) is a known prognostic factor. The aim of our analysis is to evaluate whether patients with LNI, and particularly N2 patients, should be excluded from surgical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed data from 122 patients who underwent operations at two French thoracic surgery departments between 1993 and 2011 for RCC lung metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The population consisted of 38 women and 84 men; the average age at time of metastasectomy was 63.3 years (min: 43, max: 82). LNI was identified as a prognostic factor using univariate and multivariate analysis (median survival: 107 months vs. 37 months, <jats:italic>P<\/jats:italic>\u2009=\u20090.003; HR\u2009=\u20090.384 (0.179; 0.825), <jats:italic>P<\/jats:italic>\u2009=\u20090.01, respectively). Although differences in survival between metastases at the hilar and mediastinal locations were not significant (median survival: 74 months vs. 32 months, respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.75), length of survival time was associated with disease\u2010free interval less than 12 months (median survival: 23 months vs. 94 months, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001; HR\u2009=\u20093.081 (1.193; 7.957), <jats:italic>P<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although LNI has an adverse effect on survival; long\u2010term survival can be achieved in pN+ patients. Consequently, these patients should not be excluded from surgery. Systematic lymphadenectomy should be performed to obtain more accurate staging and to determine appropriate adjuvant treatment. <jats:italic>J. Surg. Oncol. 2014 109:823\u2013829<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23593","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T09:49:37Z","timestamp":1394617777000},"page":"823-829","source":"Crossref","is-referenced-by-count":33,"title":["Systematic lymph node dissection in lung metastasectomy of renal cell carcinoma: An 18 years of experience"],"prefix":"10.1002","volume":"109","author":[{"given":"S.","family":"Renaud","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Nouvel H\u00f4pital Civil Strasbourg University Hospital Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.E.","family":"Falcoz","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Nouvel H\u00f4pital Civil Strasbourg University Hospital Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Alifano","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery H\u00f4tel Dieu. Pierre and Marie Curie University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Olland","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Nouvel H\u00f4pital Civil Strasbourg University Hospital Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Magdeleinat","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery H\u00f4tel Dieu. Pierre and Marie Curie University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Pag\u00e8s","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery H\u00f4tel Dieu. Pierre and Marie Curie University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.F.","family":"Regnard","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery H\u00f4tel Dieu. Pierre and Marie Curie University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Massard","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Nouvel H\u00f4pital Civil Strasbourg University Hospital Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20073"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl498"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2012.06.004"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25836"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66077-6"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65640-6"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64549-1"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000148261.19532.2c"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065044"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2008.03.012"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3965"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.05.006"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11851"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02303572"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800615)45:12<2981::AID-CNCR2820451216>3.0.CO;2-N"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.84.4.442"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(92)91136-W"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)90994-6"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(96)01013-5"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs534"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03803-1"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.04.047"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.04.118"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.05.021"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.06.029"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.08.034"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03602-5"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.06.096"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2008.01.045"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.23593","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.23593","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.23593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T23:17:58Z","timestamp":1696461478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.23593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,12]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1002\/jso.23593"],"URL":"https:\/\/doi.org\/10.1002\/jso.23593","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,12]]}}}