{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:06:39Z","timestamp":1783598799697,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T00:00:00Z","timestamp":1412899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Potential differences in presentation and outcome of patients with gastric cardia adenocarcinoma (GCA) and non\u2010cardia adenocarcinoma may exist. The aim of the present study was to compare the clinicopathological characteristics and the prognosis of GCA versus non\u2010cardia adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with gastric adenocarcinoma who underwent gastric resection between 2000\u20132012 were identified. Clinicopathological characteristics and outcomes were analyzed based on tumor site using a 1:2 matched\u2010control, as well as a multivariable Cox model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 743 patients, 80 (10.7%) patients were diagnosed with GCA. Patients with GCA were more likely to have intestinal tumor type (GCA: 80.4% versus non\u2010cardia: 64.2%,<jats:italic>P<\/jats:italic>\u2009=\u20090.04) or advanced AJCC T stage tumors (GCA 71.8% versus non\u2010cardia 59.2%,<jats:italic>P<\/jats:italic>\u2009=\u20090.03). GCA patients more likely underwent a total gastrectomy (GCA: 85.7% vs. non\u2010cardia: 39.8%) and had a longer length\u2010of\u2010stay (GCA: 10 days vs. non\u2010cardia: 8 days) (both<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Outcomes in early stage I patients were worse among GCA (disease\u2010free survival, 44.2%; overall survival, 42.3%) versus non\u2010GCA (disease\u2010free survival, 60.8%; overall survival, 63.0%) patients(both<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In general, disease\u2010free survival and overall survival were similar between patients with GCA versus non\u2010cardia adenocarcinoma. However, long\u2010term outcome was worse among patients with GCA and early stage disease.<jats:italic>J. Surg. Oncol. 2015 111:285\u2013292<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23799","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T22:11:11Z","timestamp":1412979071000},"page":"285-292","source":"Crossref","is-referenced-by-count":42,"title":["Clinicopathological features and prognosis of gastric cardia adenocarcinoma: A multi\u2010institutional U.S. study"],"prefix":"10.1002","volume":"111","author":[{"given":"Neda","family":"Amini","sequence":"first","affiliation":[{"name":"Department of Surgery The Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaya","family":"Spolverato","sequence":"additional","affiliation":[{"name":"Department of Surgery The Johns Hopkins University School of Medicine Baltimore 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