{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:13:10Z","timestamp":1789693990121,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:00:00Z","timestamp":1414108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The new faculty research fund of Ajou University School of Medicine and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>BRAF<\/jats:italic> mutation has received a great deal of attention in neuro\u2010oncology field, recently. This study aimed to investigate the incidence and the clinical significance of <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V600E<\/jats:italic><\/jats:sup> in low\u2010grade glial tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An institutional cohort of 105 brain tumors (51 dysembryoplastic neuroepithelial tumors (DNTs), 14 subependymal giant cell astrocytomas (SEGAs), 12 glioblastoma with neuronal marker expression (GBM\u2010N), and 28 pleomorphic xanthoastrocytomas (PXAs)) from 100 patients were investigated for the presence of <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V600E<\/jats:italic><\/jats:sup> by direct sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found frequent <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V600E<\/jats:italic><\/jats:sup> in DNTs (26\/51, 51%), SEGAs (6\/14, 42.9%), and PXAs (14\/28, 50%). In DNTs, <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V600E<\/jats:italic><\/jats:sup> was more commonly detected in tumors with extra\u2010temporal location (68.2% vs. 37.9%; <jats:italic>P<\/jats:italic>\u2009=\u20090.032). The diagnostic subgroups of tuberous sclerosis complex were not correlated with <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V600E<\/jats:italic><\/jats:sup> in patients with SEGA (<jats:italic>P<\/jats:italic>\u2009=\u20090.533). One PXA case revealed a unique duplication mutation (p.Thr599dup) of codon 599. All GMB\u2010N cases did not carry <jats:italic>BRAF<\/jats:italic> mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data indicate that <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V600E<\/jats:italic><\/jats:sup> is a common genetic alteration in low\u2010grade glial tumors with neuronal component or differentiation. High frequency of <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V600E<\/jats:italic><\/jats:sup> in DNTs and SEGAs would be useful in the differential diagnosis, and also offers a potential specific treatment targeting <jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V600E<\/jats:italic><\/jats:sup>. <jats:italic>J. Surg. Oncol. 2015 111:359\u2013364<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23822","type":"journal-article","created":{"date-parts":[[2014,10,25]],"date-time":"2014-10-25T00:27:16Z","timestamp":1414196836000},"page":"359-364","source":"Crossref","is-referenced-by-count":52,"title":["<i>BRAF V600E<\/i> mutations are frequent in dysembryoplastic neuroepithelial tumors and subependymal giant cell astrocytomas"],"prefix":"10.1002","volume":"111","author":[{"given":"Dakeun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pathology Ajou University School of Medicine Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hye","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Young","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nara","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Ohk","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon\u2010Lim","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of 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