{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:39:44Z","timestamp":1784641184529,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,8]],"date-time":"2015-03-08T00:00:00Z","timestamp":1425772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Preoperative axillary ultrasound (AUS) in clinically node\u2010negative patients may increase axillary lymph node dissection (ALND) in ACoSOG Z0011\u2010eligible patients. We hypothesize that AUS identifies operative axillary disease (&gt;3 positive nodes) in women undergoing breast conserving surgery (BCS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After IRB approval, a retrospective review of female breast cancer patients was performed; patients with clinical T1\/T2 tumors undergoing BCS were included. Clinical, radiologic, and pathologic data were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 139 eligible subjects, 119\/139 (86%) had nonpalpable axillary nodes. 47\/119 patients (40%) had abnormal AUS and 15\/47 (32%) had a positive FNA. Fourteen had ALND ;10\/14 (71%) had &gt;3 positive nodes. 6\/32 (18%) with abnormal AUS but FNA negative were sentinel lymph node (SLN) positive. Of 72 normal AUS, 15 (22%) were SLN positive; 9\/15 (60%) had ALND; 1 (11%) had &gt;3 positive nodes. When evaluating for &gt;3 positive nodes, AUS plus FNA had a sensitivity of 91%, specificity of 95%, NPV of 99%, and PPV of 71%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AUS\/FNA has a high NPV for axillary metastasis and remarkable sensitivity for three or more positive axillary nodes, therefore AUS\u2010identified metastasis should be treated as clinically node\u2010positive disease, and is appropriate even in patients planning breast conserving surgery. <jats:italic>J. Surg. Oncol. 2015 111:813\u2013818<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23885","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T01:33:15Z","timestamp":1425864795000},"page":"813-818","source":"Crossref","is-referenced-by-count":22,"title":["Impact of axillary ultrasound (AUS) on axillary dissection in breast conserving surgery (BCS)"],"prefix":"10.1002","volume":"111","author":[{"given":"Chantal","family":"Reyna","sequence":"first","affiliation":[{"name":"Comprehensive Breast Program H. Lee Moffitt Cancer Center and Research Institute Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John V.","family":"Kiluk","sequence":"additional","affiliation":[{"name":"Comprehensive Breast Program H. Lee Moffitt Cancer Center and Research Institute Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Frelick","sequence":"additional","affiliation":[{"name":"University of South Florida Morsani College of Medicine Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazanin","family":"Khakpour","sequence":"additional","affiliation":[{"name":"Comprehensive Breast Program H. Lee Moffitt Cancer Center and Research Institute Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Laronga","sequence":"additional","affiliation":[{"name":"Comprehensive Breast Program H. Lee Moffitt Cancer Center and Research Institute Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Catherine","family":"Lee","sequence":"additional","affiliation":[{"name":"Comprehensive Breast Program H. 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