{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:53:59Z","timestamp":1791237239335,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T00:00:00Z","timestamp":1430179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Leiomyosarcoma (LMS) can originate from the retroperitoneum, uterus, extremity, and trunk. It is unclear whether tumors of different origin represent discrete entities. We compared clinicopathologic features and outcomes following surgical resection of LMS stratified by site of origin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>: Patients with LMS undergoing resection at a single institution were retrospectively reviewed. Clinicopathologic variables were compared across sites. Survival was calculated using the Kaplan\u2013Meier method and compared using log\u2010rank and Cox regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1983 to 2011, 138 patients underwent surgical resection for LMS. Retroperitoneal and uterine LMS were larger, higher grade, and more commonly associated with synchronous metastases. However, disease\u2010specific survival, recurrence\u2010free survival, and recurrence patterns were not significantly different across the four sites. Synchronous metastases (HR 3.20, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), but not site of origin, size, grade, or margin status, were independently associated with worse DSS. A significant number of recurrences and disease\u2010related deaths were noted beyond 5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although larger and higher grade, retroperitoneal and uterine LMS share similar survival and recurrence patterns with their trunk and extremity counterparts. LMS of various anatomic sites may not represent distinct disease processes based on clinical outcomes. The presence of metastatic disease remains the most important prognostic factor for LMS. <jats:italic>J. Surg. Oncol. 2015 111:808\u2013812<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23904","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T08:08:43Z","timestamp":1430381323000},"page":"808-812","source":"Crossref","is-referenced-by-count":20,"title":["Leiomyosarcoma: One disease or distinct biologic entities based on site of origin?"],"prefix":"10.1002","volume":"111","author":[{"given":"David J.","family":"Worhunsky","sequence":"first","affiliation":[{"name":"Department of Surgery Stanford University Medical Center Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihir","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Surgery Stanford University Medical Center Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepideh","family":"Gholami","sequence":"additional","affiliation":[{"name":"Department of Surgery 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