{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:38:55Z","timestamp":1773268735086,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to investigate prognostic factors for low rectal cancer patients undergoing intersphincteric resection (ISR) following neoadjuvant chemoradiation (CRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed 163 primary rectal cancer patients without distant metastasis who underwent ISR following neoadjuvant CRT between January 2006 and December 2011. Prognostic factors for disease\u2010free survival (DFS) and local recurrence\u2010free survival (LRFS) were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up period was 53 months (range, 0\u201382 months). Kaplan\u2013Meier survival analysis indicated different 3\u2010year DFS (stage 0, 96.2%; I, 84.8%; II, 72.9%; III, 38.0%) and 3\u2010year LRFS (stage 0, 100.0%; I, 92.4%; II, 91.1%; III, 70.9%) according to pathologic TNM stages, particularly stage III. Multivariable Cox regression analysis suggested that DFS was associated with ypT (3\/4 vs. 0\/1\/2) and ypN (1\/2 vs. 0) stages, whereas LRFS with ypN stage (1\/2 vs. 0), tumor size (\u22653.5\u2009cm vs. &lt;3.5\u2009cm), and tumor height from the anal verge (\u22642\u2009cm vs. &gt;2\u2009cm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ISR following CRT could be feasible in stage\u2010I and II low rectal cancer patients, but might be related to poor oncologic outcomes in those with stage\u2010III disease. The indication for ISR or abdominoperineal resection should be carefully evaluated in cases of low rectal cancer with suspicious lymph node metastasis after CRT. <jats:italic>J. Surg. Oncol. 2015 111:1054\u20131058<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.23932","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T20:20:37Z","timestamp":1431634837000},"page":"1054-1058","source":"Crossref","is-referenced-by-count":21,"title":["Prognostic factors for low rectal cancer patients undergoing intersphincteric resection after neoadjuvant chemoradiation"],"prefix":"10.1002","volume":"111","author":[{"given":"Soo Young","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery Chonnam National University Hwasun Hospital and Medical School Hwasun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Seon","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Surgery Chonnam National University Hwasun Hospital and Medical School Hwasun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hun Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Chonnam National University Hwasun Hospital and Medical School Hwasun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Chonnam National University Hwasun Hospital and Medical School Hwasun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Chonnam National University Hwasun Hospital and Medical School Hwasun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeong Rok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Chonnam National University Hwasun Hospital and Medical School Hwasun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,14]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"876","article-title":"Modified anoabdominal rectal resection and colonic J\u2010pouch anal anastomosis for lower rectal carcinoma: Preliminary report","volume":"112","author":"Kusunoki M","year":"1992","journal-title":"Surgery"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800810944"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.04.010"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8677"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-012-2317-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181ad6511"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318195e17c"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000979"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0134-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.05.036"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31815c29ff"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e31819f5fa2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1277-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318236c448"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3573-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3762-y"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0047-3"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31823785f6"},{"key":"e_1_2_6_20_1","unstructured":"National Comprehensive Cancer Network: Rectal cancer clinical practice guidelines in oncology. 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