{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:56Z","timestamp":1786978076077,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T00:00:00Z","timestamp":1439769600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The aim of this study was to determine if neutrophil\u2010to\u2010lymphocyte ratio (NLR) and platelet\u2010to\u2010lymphocyte ratio (PLR) were predictive of malignancy in mucin\u2010producing pancreatic cystic neoplasms (MpPCN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and twenty patients with MpPCN were retrospectively reviewed. Malignant neoplasms were defined as neoplasms harbouring invasive carcinoma or high grade dysplasia. A high NLR and PLR were defined as \u22652.551 and \u2265208.1, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High NLR was significantly associated with symptomatic tumors, larger tumors, solid component, main\u2010duct IPMN, and Sendai high risk category. High PLR was significantly associated with jaundice and Sendai high risk category. On univariate analyses, symptomatic tumors, jaundice, solid component, dilated pancreatic duct, and both a high NLR and PLR were significant predictors of malignant and invasive MpPCN. On multivariate analyses, solid component and dilated pancreatic duct were independent predictors of malignant and invasive MpPCN. PLR was an independent predictor for invasive MpPCN. When MpPCN were stratified by the Fukuoka and Sendai Guidelines, both a high NLR and PLR were significantly associated with malignant neoplasms within the high risk categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      PLR is an independent predictor of invasive carcinoma. The addition of PLR as a criterion to the FCG and SCG significantly improved the predictive value of these guidelines in detecting invasive neoplasms.\n                      <jats:italic>J. Surg. Oncol. 2015; 112:366\u2013371<\/jats:italic>\n                      . \u00a9 2015 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.23997","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T10:10:10Z","timestamp":1439806210000},"page":"366-371","source":"Crossref","is-referenced-by-count":39,"title":["Are preoperative blood neutrophil\u2010to\u2010lymphocyte and platelet\u2010to\u2010lymphocyte ratios useful in predicting malignancy in surgically\u2010treated mucin\u2010producing pancreatic cystic neoplasms?"],"prefix":"10.1002","volume":"112","author":[{"given":"Brian K. P.","family":"Goh","sequence":"first","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Singapore"},{"name":"Duke\u2010NUS Graduate Medical School Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien M. Y.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Yip","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ser\u2010Yee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor T. W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon\u2010Hua","family":"Thng","sequence":"additional","affiliation":[{"name":"Department of Oncologic Imaging National Cancer Centre Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert S. C.","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Radiology Singapore General Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W. M.","family":"Tai","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng\u2010Chung","family":"Cheow","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierce K. H.","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Singapore"},{"name":"Duke\u2010NUS Graduate Medical School Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"London L. P. J.","family":"Ooi","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplantation Surgery Singapore General Hospital Singapore"},{"name":"Duke\u2010NUS Graduate Medical School Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Y. 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