{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:47:49Z","timestamp":1784641669789,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Phaeochromocytomas and paragangliomas arise from the same chromaffin cell, but evidence suggests they do not represent a single clinical entity. The aim of this study was to compare clinical presentations, outcomes of surgical and oncological treatments and survival in patients with phaeochromocytomas and paragangliomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was undertaken of all patients treated for these conditions at our centre between 1983 and 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and six patients (88 adults, 18 children) with phaeochromocytoma (n\u2009=\u200983) or paraganglioma (n\u2009=\u200923) were studied. Catecholamine symptoms and incidentalomas were the main presentations in phaeochromocytoma patients (67% and 17%) respectively, but in those with paragangliomas pain (39%) was more common (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). More paragangliomas were malignant (14\/23 vs 9\/83, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), larger (9.17\u2009\u00b1\u20094.95\u2009cm vs. 5.8\u2009\u00b1\u20093.44\u2009cm, <jats:italic>P<\/jats:italic>\u2009=\u20090.001) and had a higher rate of conversion to open surgery (<jats:italic>P<\/jats:italic>\u2009=\u2009&lt;0.01), more R2 resections, more postoperative complications and a longer hospital stay (<jats:italic>P<\/jats:italic>\u2009=\u20090.014). MIBG uptake in malignant paragangliomas was lower than in malignant phaeochromocytomas (36% vs. 100%, <jats:italic>P<\/jats:italic>\u2009=\u20090.002) and disease stabilisation was achieved in 29% and 86% of patients respectively. <jats:sup>90<\/jats:sup>Y\u2010DOTA\u2010octreotate had a 78% response rate in malignant paragangliomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical differences between paragangliomas and phaeochromocytomas support the view that they should be considered as separate clinical entities. <jats:italic>J. Surg. Oncol. 2015; 112:486\u2013491<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24030","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T09:55:10Z","timestamp":1441360510000},"page":"486-491","source":"Crossref","is-referenced-by-count":21,"title":["Phaeochromocytomas and Paragangliomas: A difference in disease behaviour and clinical outcomes"],"prefix":"10.1002","volume":"112","author":[{"given":"Tarek","family":"Ezzat Abdel\u2010Aziz","sequence":"first","affiliation":[{"name":"Centre for Endocrine Surgery University College London Hospital and Great Ormond Street Hospital London UK"},{"name":"Department of General Surgery University of Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Prete","sequence":"additional","affiliation":[{"name":"Centre for Endocrine Surgery University College London Hospital and Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Conway","sequence":"additional","affiliation":[{"name":"Departments of Oncology Endocrinology and Nuclear Medicine University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Gaze","sequence":"additional","affiliation":[{"name":"Departments of Oncology Endocrinology and Nuclear Medicine University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamshed","family":"Bomanji","sequence":"additional","affiliation":[{"name":"Departments of Oncology Endocrinology and Nuclear Medicine University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bouloux","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Oncology and Neuroendocrine Unit Royal Free Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Khoo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Oncology and Neuroendocrine Unit Royal Free Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn","family":"Caplin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Oncology and Neuroendocrine Unit Royal Free Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Mushtaq","sequence":"additional","affiliation":[{"name":"Centre for Endocrine Surgery University College London Hospital and Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Smart","sequence":"additional","affiliation":[{"name":"Centre for Endocrine Surgery University College London Hospital and Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom R.","family":"Kurzawinski","sequence":"additional","affiliation":[{"name":"Centre for Endocrine Surgery University College London Hospital and Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1353.059"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1986.tb02755.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1353.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.21612"},{"key":"e_1_2_6_6_1","first-page":"354","article-title":"Prevalence of clinically unsuspected pheochromocytoma. 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