{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:08:06Z","timestamp":1787069286365,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ensign Endowment for Ovarian Cancer Research (KM and LDR)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>To determine the significance of depth and extent of lymphovascular space invasion (LVSI) on lymph node metastasis and recurrence in endometrial cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case\u2010control study was conducted to examine LVSI\u2010positive (n\u2009=\u200970) and LVSI\u2010negative (n\u2009=\u2009641) stage I\u2013III endometrial cancer cases that underwent hysterectomy\u2010based surgical staging. The risk of lymph node metastasis and distant recurrence was estimated based on LVSI patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In multivariate analysis, deep (&gt;50% invasion), and extensive (\u22657 foci\/slide) LVSI patterns had a significantly increased risk of lymph node metastasis (incidence 57.6% and 72.7%, odds ratio 33.8 and 49.9, respectively,\n                      <jats:italic>P\u2009<\/jats:italic>\n                      &lt;\u20090.001) as compared to other traditional uterine factors (&gt;50% myometrial tumor invasion, cervical stromal invasion, and adnexal involvement: incidence range 30.4\u201337.9%, odds ratio range 3.80\u20137.03). Deep and extensive of LVSI patterns were both significantly correlated to distant recurrence (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      &lt;\u20090.001). Among women who received postoperative chemotherapy, deep and extensive LVSI patterns did not have increased risks for distant recurrence compared to no LVSI (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.47 and 0.32, respectively). Among women who received postoperative radiotherapy, the depth of LVSI was significantly associated with recurrence outside the radiated field (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Depth and extent of LVSI are important predictors for lymph node metastasis and distant recurrence in endometrial cancer.\n                      <jats:italic>J. Surg. Oncol. 2015;112:669\u2013676<\/jats:italic>\n                      . \u00a9 2015 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.24049","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T01:17:05Z","timestamp":1442884625000},"page":"669-676","source":"Crossref","is-referenced-by-count":55,"title":["Impact of depth and extent of lymphovascular space invasion on lymph node metastasis and recurrence patterns in endometrial cancer"],"prefix":"10.1002","volume":"112","author":[{"given":"Koji","family":"Matsuo","sequence":"first","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology University of Southern California Los Angeles California"},{"name":"Norris Comprehensive Cancer Center University of Southern California 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