{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:45:12Z","timestamp":1787849112090,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,10,18]],"date-time":"2015-10-18T00:00:00Z","timestamp":1445126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA127328\u201003"],"award-info":[{"award-number":["R01 CA127328\u201003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NR05342"],"award-info":[{"award-number":["NR05342"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NR011093"],"award-info":[{"award-number":["NR011093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 CA009599"],"award-info":[{"award-number":["T32 CA009599"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>We assessed the cumulative incidence, symptoms, and risk factors for upper\u2010extremity lymphedema in breast cancer and melanoma patients undergoing sentinel lymph node biopsy or axillary lymph node dissection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were recruited preoperatively (time 0) and assessed at 6, 12, and 18 months postoperatively. Limb volume change (LVC) was measured by perometry. Lymphedema was categorized as none, mild (LVC 5\u20139.9%), or moderate\/severe (LVC\u226510%). Symptoms were assessed with a validated lymphedema instrument. Longitudinal logistic regression analyses were conducted to identify risk factors associated with moderate\/severe lymphedema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 205 breast cancer and 144 melanoma patients, the cumulative incidence of moderate\/severe lymphedema at 18 months was 36.5% and 35.0%, respectively. However, in adjusted analyses, factors associated with moderate\/severe lymphedema were breast cancer (OR 2.0, <jats:italic>P\u2009<\/jats:italic>=\u20090.03), body mass index \u226530\u2009kg\/m<jats:sup>2<\/jats:sup> (OR 1.6, <jats:italic>P\u2009<\/jats:italic>=\u20090.04), greater number of lymph nodes removed (OR 1.05, <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.01), and longer interval since surgery (OR 2.33 at 18 months, <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lymphedema incidence increased over time in both cohorts. However, the adjusted risk of moderate\/severe lymphedema was two\u2010fold higher in breast cancer patients. These results may be attributed to surgical treatment of the primary tumor in the breast and more frequent use of radiation. <jats:italic>J. Surg. Oncol. 2015;112:834\u2013840<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24068","type":"journal-article","created":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T03:02:43Z","timestamp":1445223763000},"page":"834-840","source":"Crossref","is-referenced-by-count":27,"title":["The long\u2010term risk of upper\u2010extremity lymphedema is two\u2010fold higher in breast cancer patients than in melanoma patients"],"prefix":"10.1002","volume":"112","author":[{"given":"Rachel K.","family":"Voss","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate D.","family":"Cromwell","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Ju","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane M.","family":"Armer","sequence":"additional","affiliation":[{"name":"Sinclair School of Nursing University of Missouri Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merrick I.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Gershenwald","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob R.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Sinclair School of Nursing University of Missouri Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona F.","family":"Shaitelman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice N.","family":"Cormier","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/CMR.0b013e3283632c83","article-title":"Prospective assessment of lymphedema incidence and lymphedema\u2010associated symptoms following lymph node surgery for melanoma","volume":"23","author":"Hyngstrom JR","year":"2013","journal-title":"Melanoma Res"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25458"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2005.05.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000143271.32568.2b"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.t01-1-02622.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.10.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2002.02405.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(02)01230-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800731119"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830601)51:11<2152::AID-CNCR2820511134>3.0.CO;2-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70076-7"},{"key":"e_1_2_7_14_1","first-page":"26","article-title":"Reliability and limits of agreement of circumferential, water displacement, and optoelectronic volumetry in the measurement of upper limb lymphedema","volume":"40","author":"Deltombe T","year":"2007","journal-title":"Lymphology"},{"key":"e_1_2_7_15_1","first-page":"132","article-title":"Comparative study between mobile infrared optoelectronic volumetry with a perometer and two commonly used methods for the evaluation of arm volume in patients with breast cancer related lymphedema of the arm","volume":"46","author":"Adriaenssens N","year":"2013","journal-title":"Lymphology"},{"key":"e_1_2_7_16_1","unstructured":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Breast Cancer. 2015; Available from:http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/breast.pdf"},{"key":"e_1_2_7_17_1","unstructured":"National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Melanoma. 2015 [cited 2015 February 23]; Version 2.2015: [Available from:http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/melanoma.pdf"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.3725"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-200311000-00004"},{"key":"e_1_2_7_20_1","first-page":"161","article-title":"Minimal limb volume change has a significant impact on breast cancer survivors","volume":"42","author":"Cormier JN","year":"2009","journal-title":"Lymphology"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2655-2"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2006.08.018"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-014-0414-x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.05.013"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.12.041"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1688-1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2013.0036"},{"key":"e_1_2_7_28_1","unstructured":"Shaitelman SF CK Chiang YJ DeSnyder SM et al.: Radiation targets and the development of breast cancer\u2010related lymphedema: A systematic review of the literature. 11th National Lymphedema Network International Conference.2014. Washington DC."},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.04.030"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12311"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3357-8"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10019-010-0047-3"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.3517"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114597"},{"key":"e_1_2_7_35_1","first-page":"2","article-title":"Early diagnosis of lymphedema using multiple frequency bioimpedance","volume":"34","author":"Cornish BH","year":"2001","journal-title":"Lymphology"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2006.4.51"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2014.0035"},{"key":"e_1_2_7_38_1","first-page":"118","article-title":"Post\u2010breast cancer lymphedema: Incidence increases from 12 to 30 to 60 months","volume":"43","author":"Armer JM","year":"2010","journal-title":"Lymphology"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.24068","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.24068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:38:49Z","timestamp":1696405129000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.24068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,18]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1002\/jso.24068"],"URL":"https:\/\/doi.org\/10.1002\/jso.24068","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,18]]}}}