{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:24:54Z","timestamp":1770895494189,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Historically dermal melanoma (DM) has been labeled as either stage IIIB (in\u2010transit) or stage IV (M1a) disease. We sought to investigate the natural history of DM and the utility and prognostic significance of sentinel lymph node biopsy (SLNB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with DM undergoing SLNB at a single center from 1998 to 2009 were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010three patients met criteria, 10 (12%) patients had a positive SLNB. Of those, 5 (50%) recurred (all with distant disease). Twenty\u2010one (29%) of the 73 SLNB negative patients recurred and of those, 15 (71%) developed distant metastases, whereas 6 (29%) developed local or regional recurrence, including two false\u2010negative regional nodal recurrences. No in\u2010transit recurrences were recorded. Five\u2010year recurrence\u2010free and disease\u2010specific survival was significantly better for patients with a negative SLNB versus positive SLNB (56.8% vs. 22.2% <jats:italic>P\u2009<\/jats:italic>=\u20090.02, 81.1% vs. 61.0%, <jats:italic>P\u2009<\/jats:italic>=\u20090.05, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SLNB has prognostic significance for RFS and DSS, and should be utilized in the management of DM based on a &gt;10% yield and low false\u2010negative rate. Our data demonstrate patients with DM do not recur in an in\u2010transit fashion, which along with the survival outcomes suggest the behavior of DM is consistent with primary cutaneous melanoma of similar thickness rather than an isolated in\u2010transit or distant dermal metastasis from a regressed cutaneous primary. <jats:italic>J. Surg. Oncol. 2016;113:98\u2013102<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24088","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T09:33:14Z","timestamp":1449739994000},"page":"98-102","source":"Crossref","is-referenced-by-count":16,"title":["Dermal melanoma: A report on prognosis, outcomes, and the utility of sentinel lymph node biopsy"],"prefix":"10.1002","volume":"113","author":[{"given":"Matthew P.","family":"Doepker","sequence":"first","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary J.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer N.","family":"Harb","sequence":"additional","affiliation":[{"name":"Department of Cutaneous 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