{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T07:52:02Z","timestamp":1784361122795,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Uehara Zaidan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Karyopherin \u03b1 2 (KPNA2) is a member of the Karyopherin \u03b1 family and has recently been reported to play an important role in tumor progression. The aim of the current study was to elucidate the clinicopathological significance of KPNA2 over\u2010expression in colorectal cancer (CRC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>KPNA2 expression was evaluated by immunohistochemistry in 122 surgically resected CRC and 13 biopsy specimens obtained at colonoscopy during screening for preoperative hyperthermochemoradiation therapy (HCRT). The association between KPNA2 expression and clinicopathological features and preoperative HCRT efficacy were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The high and low KNPA2 expression groups were comprised of 91 (74.6%) and 31 CRC patients, respectively. A significant association was observed between high expression and lymphatic invasion (<jats:italic>P<\/jats:italic>\u2009=\u20090.0245). KPNA2 high expression group had decreased overall survival (<jats:italic>P<\/jats:italic>\u2009=\u20090.00374). Multivariate analysis demonstrated high KPNA2 expression was independently associated with poor prognosis. Histological examinations revealed 11 (84.6%) and 2 (15.4%) of cases were KPNA2 positive and negative, respectively. Pathological complete response (pCR) was observed in 9.1% of KPNA2\u2010positive cases and 100% of KPNA2\u2010negative cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High KPNA2 expression was found to be associated with poor prognosis and resistance to HCRT. <jats:italic>J. Surg. Oncol. 2016;113:213\u2013217<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24114","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T20:59:26Z","timestamp":1449781166000},"page":"213-217","source":"Crossref","is-referenced-by-count":22,"title":["KPNA2 over\u2010expression is a potential marker of prognosis and therapeutic sensitivity in colorectal cancer patients"],"prefix":"10.1002","volume":"113","author":[{"given":"Takahiro","family":"Takada","sequence":"first","affiliation":[{"name":"Department of General Surgical Science Graduate School of Medicine Gunma University Showamachi Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichi","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science Graduate School of Medicine Gunma University Showamachi Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science Graduate School of Medicine Gunma University Showamachi Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Ohsone","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science Graduate School of Medicine Gunma University Showamachi Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Tatsuki","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science Graduate School of Medicine Gunma University Showamachi Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinaga","family":"Suto","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science Graduate School of Medicine Gunma University Showamachi Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihide","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science Graduate School of Medicine Gunma University Showamachi Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science Graduate School of Medicine Gunma University Showamachi Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Yokobori","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Oncology Graduate School of Medicine Gunma University Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kuwano","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science Graduate School of Medicine Gunma University Showamachi Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_8_4_1","first-page":"392","volume-title":"Colorectal Cancer in World Cance Report 2014","author":"Bosman FT","year":"2014"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.8.1008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","unstructured":"Colorectal Cancer Collaborative Group: Adjuvant radiotherapy for rectal cancer: A systematic overview of 8 507 patients from 22 randomised trials. 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