{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:34:38Z","timestamp":1787495678024,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background &amp; Objectives<\/jats:title>\n                    <jats:p>The effect of cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with rectal peritoneal metastases (PM) is unclear. This case\u2010control study aims to assess the results of cytoreduction and HIPEC in patients with rectal PM compared to colon PM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Colorectal PM patients treated with complete macroscopic cytoreduction and HIPEC were included. Two colon cancer patients were case\u2010matched for each rectal cancer patient, based on prognostic factors (T stage, N stage, histology type, and extent of PM). Short\u2010 and long\u2010term outcomes were compared between both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 317 patients treated with complete macroscopic cytoreduction and HIPEC, 29 patients (9.1%) had rectal PM. Fifty\u2010eight colon cases were selected as control patients. Baseline characteristics were similar between groups. Major morbidity was 27.6% and 34.5% in the rectal and colon group, respectively (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      =\u20090.516). Median disease\u2010free survival was 13.5 months in the rectal group and 13.6 months in the colon group (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      =\u20090.621). Two\u2010 and five\u2010year overall survival rates were 54%\/32% in rectal cancer patients, and 61%\/24% in colon cancer patients (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      =\u20090.987).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Cytoreduction and HIPEC in selected patients with rectal PM is feasible and provides similar outcomes as in colon cancer patients. Rectal PM should not be regarded a contra\u2010indication for cytoreduction and HIPEC in selected patients.\n                      <jats:italic>J. Surg. Oncol. 2016;113:548\u2013553<\/jats:italic>\n                      . \u00a9 2016 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.24169","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T02:37:08Z","timestamp":1452566228000},"page":"548-553","source":"Crossref","is-referenced-by-count":23,"title":["Cytoreductive surgery and HIPEC offers similar outcomes in patients with rectal peritoneal metastases compared to colon cancer patients: a matched case control study"],"prefix":"10.1002","volume":"113","author":[{"given":"Geert A.","family":"Simkens","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Catharina Hospital Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thijs R.","family":"van Oudheusden","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Catharina Hospital Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidde J.","family":"Braam","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology St. Antonius Hospital Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinus J.","family":"Wiezer","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology St. Antonius Hospital Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon W.","family":"Nienhuijs","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Catharina Hospital Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm J.","family":"Rutten","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Catharina Hospital Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"van Ramshorst","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology St. Antonius Hospital Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignace H.","family":"de Hingh","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Catharina Hospital Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25596"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8679"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25356"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3145-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23722"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2013.05.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.04.009"},{"key":"e_1_2_7_9_1","first-page":"247107","article-title":"Approach to rectal cancer surgery","volume":"2012","author":"Chua TC","year":"2012","journal-title":"Int J Surg Oncol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0189-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2787-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e3181a58f30"},{"key":"e_1_2_7_14_1","first-page":"9286","article-title":"Update on the prevention of local recurrence and peritoneal metastases in patients with colorectal cancer","volume":"20","author":"Sugarbaker PH","year":"2014","journal-title":"World J Gastroenterol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23784"},{"key":"e_1_2_7_16_1","article-title":"Predictors of severe morbidity after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for patients with colorectal peritoneal carcinomatosis","author":"Simkens GA","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2009.02.010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4516"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.82"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt591"},{"key":"e_1_2_7_22_1","unstructured":"IKNL Dutch National Cancer Registry. 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