{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T08:26:44Z","timestamp":1784795204100,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Balloon kyphoplasty (BKP) is a percutaneous treatment for cancer\u2010related vertebral compression fractures (VCF). Posterior vertebral body wall (PVBW) involvement is considered a contraindication for BKP. This study assesses whether BKP is safe and effective for cancer\u2010related VCFs involving the PVBW.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study analyzed data on 158 patients with 228 cancer\u2010related VCFs who underwent BKP. One hundred and twelve patients had VCFs with PVBW defects, and 46 had VCFs with no PVBW defect. Outcomes were assessed preoperatively and at 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the PVBW defect group, mean pain score decreased from 7.5 to 3.6 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), EQ5D increased from 0.39 to 0.48 and Oswestry Disability Index (ODI) decreased from 50 to 42. Cement leaks occurred in 31%. In the PVBW intact group, mean pain decreased from 7.3 to 3.3 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), EQ5D increased from 0.35 to 0.48 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and ODI decreased from 53 to 50. Cement leaks occurred in 20%. No significant difference was observed in functional improvements between groups. Radiographically kyphotic angle and anterior and middle vertebral body heights were significantly worse in the PVBW defect group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BKP can alleviate pain and improve QoL and function in patients with cancer\u2010related VCFs with PVBW defects with no appreciable increase in risk. <jats:italic>J. Surg. Oncol. 2016;113:835\u2013842<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24222","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T05:42:52Z","timestamp":1458538972000},"page":"835-842","source":"Crossref","is-referenced-by-count":23,"title":["Is balloon kyphoplasty safe and effective for cancer\u2010related vertebral compression fractures with posterior vertebral body wall defects?"],"prefix":"10.1002","volume":"113","author":[{"given":"Sean","family":"Molloy","sequence":"first","affiliation":[{"name":"The Royal National Orthopaedic Hospital Stanmore United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew D.","family":"Sewell","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery The James Cook University Hospital Middlesbrough United 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