{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T23:27:36Z","timestamp":1786750056845,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:00:00Z","timestamp":1459728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Intraoperative adjuncts for the localization of parathyroid glands in parathyroid surgery are limited. The aim of this study is to assess the usefulness of indocyanine green (ICG) near\u2010infrared (NIR) fluorescent imaging in patients undergoing surgery for primary hyperparathyroidism (PHPT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ICG imaging was performed in 33 patients undergoing parathyroidectomy (PTX). Thyroid and parathyroid ICG uptake were assessed and independently verified on a grading scale. Clinical variables were recorded and analyzed for factors associated with ICG uptake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 112 glands identified by naked eye, 104 (92.9%) demonstrated ICG uptake. Concomitant ICG fluorescence was identified in the thyroid in all patients. There was a trend toward increased ICG fluorescence in patients &lt;60 years of age (<jats:italic>P<\/jats:italic>\u2009=\u20090.05). A higher degree of fluorescence was seen in patients presenting with pre\u2010operative calcium values &gt;11\u2009mg\/dl (<jats:italic>P<\/jats:italic>\u2009=\u20090.04) and in those parathyroids larger than 10\u2009mm (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). All patients had biochemically proven cure. No patients who underwent subtotal PTX (n\u2009=\u20096) developed postoperative hypoparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ICG can reliably localize parathyroid glands during PTX and additionally allow for assessment of parathyroid perfusion in patients undergoing subtotal resection. Concomitant fluorescence of the thyroid gland limits ICG's usefulness in directing the course of PTX. <jats:italic>J. Surg. Oncol. 2016;113:771\u2013774<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24240","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T05:35:26Z","timestamp":1459748126000},"page":"771-774","source":"Crossref","is-referenced-by-count":80,"title":["The utility of indocyanine green near infrared fluorescent imaging in the identification of parathyroid glands during surgery for primary hyperparathyroidism"],"prefix":"10.1002","volume":"113","author":[{"given":"Nisar","family":"Zaidi","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Bucak","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Cleveland Clinic Cleveland 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