{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:27:26Z","timestamp":1792182446885,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T00:00:00Z","timestamp":1459900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The Toronto extremity salvage score (TESS) assesses physical function following limb salvage for bone and soft tissue sarcoma. In 2012, Clayer et al. showed increasing age affects the TESS score in normal individuals. The purpose of this study was to investigate what other patient factors affect outcome?<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the TESS scores, age, sex, BMI, diagnosis, smoking status, and social deprivation score of patients who have undergone limb salvage in our unit. Data were extracted from our tumor database and reviewed. Statistical analysis was performed using Wilcoxon pairwise test and linear regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and ninety\u2010eight TESS scores were found for 198 patients. Data were analyzed separating upper limb (UL) and lower limb (LL) tumors. In the UL group, being female (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) and having a bone lesion (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were associated with a lower TESS score. In the LL group, being female (<jats:italic>P<\/jats:italic>\u2009=\u20090.04), increasing age (<jats:italic>P<\/jats:italic>\u2009=\u20090.002), having a bone lesion (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), increasing BMI (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and smoking (<jats:italic>P<\/jats:italic>\u2009=\u20090.005) were associated with a lower TESS score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Analysis has shown that female sex, increasing age and BMI, smoking and having a bone lesion have an adverse effect on physical function following limb salvage, as indicated by the mean TESS score. <jats:italic>J. Surg. 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