{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:47:59Z","timestamp":1791110879441,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T00:00:00Z","timestamp":1461542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To review our 25\u2010year experience with hyperthermic intra\u2010peritoneal chemotherapy (HIPEC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Combining cytoreductive surgery (CRS) and HIPEC as local treatments for peritoneal carcinomatosis (PC) was proposed 25 years ago.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective database of all patients undergoing HIPEC for PC since 1989 was searched for clinicopathological data, 90\u2010day morbidity and mortality, and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1,125 HIPEC procedures, PC origin was colorectal (342; 30%), ovarian (271; 24%), pseudomyxoma peritonei (189; 17%), gastric (127; 11%), malignant mesothelioma (84; 8%), or other (112; 10%). Between 2004\u20132009 (n\u2009=\u2009321) and 2010\u20132015 (n\u2009=\u2009560), the median peritoneal cancer index decreased (11 vs. 8; <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001), fewer patients underwent incomplete cytoreduction (CC2\u20103: 4% vs. 0.5%; <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001), and more were included in randomized trials (5% vs. 16%; <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001). Postoperative morbidity (52% vs. 50%, <jats:italic>P\u2009<\/jats:italic>=\u20090.672) was not different, but mortality significantly decreased (5% vs. 2%; <jats:italic>P\u2009<\/jats:italic>=\u20090.030). Median overall\u2010survival was 42 months, and improved significantly for each 5\u2010year period except for 2006\u20132010 vs. 2011\u20132015 (<jats:italic>P\u2009<\/jats:italic>=\u20090.097). The 10\u2010year survival without recurrence was 53%, 14%, 4%, 10%, and 9% for pseudomyxoma, mesothelioma, ovarian, colorectal, and gastric PC, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that CRS and HIPEC provide long\u2010term survival irrespective of PC origin, and survival improves with experience. <jats:italic>J. Surg. Oncol. 2016;113:796\u2013803<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24248","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T13:14:07Z","timestamp":1461590047000},"page":"796-803","source":"Crossref","is-referenced-by-count":117,"title":["What made hyperthermic intraperitoneal chemotherapy an effective curative treatment for peritoneal surface malignancy: A 25\u2010year experience with 1,125 procedures"],"prefix":"10.1002","volume":"113","author":[{"given":"Guillaume","family":"Passot","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology CHU Lyon Sud Hospices civils de Lyon University of Lyon France"},{"name":"EMR 37\u201038 Lyon 1 University Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Vaudoyer","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology CHU Lyon Sud Hospices civils de Lyon University of Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Villeneuve","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology CHU Lyon Sud Hospices civils de Lyon University of Lyon France"},{"name":"EMR 37\u201038 Lyon 1 University Lyon France"},{"name":"Department of Pole IMER CHU Lyon Sud Hospices civils de Lyon University of Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahan","family":"Kepenekian","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology CHU Lyon Sud Hospices civils de Lyon University of Lyon France"},{"name":"EMR 37\u201038 Lyon 1 University Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie\u2010Claude","family":"Beaujard","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology CHU Lyon Sud Hospices civils de Lyon University of Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoual","family":"Bakrin","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology CHU Lyon Sud Hospices civils de Lyon University of Lyon France"},{"name":"EMR 37\u201038 Lyon 1 University Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddy","family":"Cotte","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology CHU Lyon Sud Hospices civils de Lyon University of Lyon France"},{"name":"EMR 37\u201038 Lyon 1 University Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois\u2010Noel","family":"Gilly","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology CHU Lyon Sud Hospices civils de Lyon University of Lyon France"},{"name":"EMR 37\u201038 Lyon 1 University Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Glehen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology CHU Lyon Sud Hospices civils de Lyon University of Lyon France"},{"name":"EMR 37\u201038 Lyon 1 University Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000115)88:2<358::AID-CNCR16>3.0.CO;2-O"},{"key":"e_1_2_7_3_1","first-page":"83","article-title":"Rationale for integrating early postoperative intraperitoneal chemotherapy into the surgical treatment of gastrointestinal cancer","volume":"16","author":"Sugarbaker PH","year":"1989","journal-title":"Semin Oncol"},{"key":"e_1_2_7_4_1","first-page":"164","article-title":"Intra\u2010Peritoneal Chemo\u2010Hyperthermia (CHIP): A new therapy in the treatment of the peritoneal seedings. 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