{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:50:48Z","timestamp":1793569848168,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T00:00:00Z","timestamp":1460505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32CA126607"],"award-info":[{"award-number":["T32CA126607"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA006973"],"award-info":[{"award-number":["P30CA006973"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003341","name":"Sarcoma Foundation of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Retroperitoneal sarcomas are connective tissue tumors arising in the retroperitoneum. Surgical resection is the mainstay of treatment. Debate has arisen over extent of resection, changes in histological classification\/grading, and interest in incorporating radiotherapy. Therefore, we reviewed our institution's experience to evaluate prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart review of all primary RPS patients at Johns Hopkins Hospital from 1994 to 2010. Histologic diagnosis and grading were re\u2010evaluated with current criteria. Prognostic factors for survival, and recurrence were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred thirty\u2010one primary RPS patients met inclusion criteria. Median survival for patients who undergo en\u2010bloc resection to negative margins (R0\/R1) is 81.7 months. Surgical margins and grade were the most important factors for survival along with age, gender, presence of metastases and resection of \u22655 organs. Five\u2010year survival for R0\/R1 resection was 60%, similar to compartmental resection. Radiotherapy significantly decreased local recurrence (<jats:italic>P<\/jats:italic>\u2009=\u20090.026) on multivariate analysis. Grade in leiomyosarcomas and dedifferentiation in liposarcomas dictated patterns of local versus distal recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>En bloc surgical resection to R0\/R1 margins remains the cornerstone of therapy and provides comparable outcomes to compartmental resections. Grade remains important for prognosis, and histology dictates recurrence patterns. Radiotherapy appears promising for local control and warrants further investigation. <jats:italic>J. Surg. Oncol. 2016;114:56\u201364<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24256","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T04:08:50Z","timestamp":1460606930000},"page":"56-64","source":"Crossref","is-referenced-by-count":49,"title":["Long\u2010term outcomes in treatment of retroperitoneal sarcomas: A 15 year single\u2010institution evaluation of prognostic features"],"prefix":"10.1002","volume":"114","author":[{"given":"Eihab","family":"Abdelfatah","sequence":"first","affiliation":[{"name":"Department of Surgery The Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela A.","family":"Guzzetta","sequence":"additional","affiliation":[{"name":"Department of Surgery The Johns Hopkins University School of Medicine Baltimore 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