{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:25:47Z","timestamp":1773008747415,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin\u2010directed therapy, exerting prominent cytotoxic activity, and antivascular effects. Its efficacy in angiosarcoma has not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter retrospective analysis reviewed patients who underwent electrochemotherapy from 2007 to 2014 for superficial advanced angiosarcomas. Bleomycin was administered intravenously and delivered within tumors by means of percutaneously applied electric pulses, according to the European Standard Operating Procedures for Electrochemotherapy. Tumor assessment was performed using RECIST (version 1.1). Toxicity (CTCAE, v4.0) and local progression\u2010free survival (LPFS) were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen patients (13 with locally advanced and 6 with metastatic angiosarcomas) were treated. Tumor sites were: scalp (n\u2009=\u20095), breast (n\u2009=\u20098), other skin sites (n\u2009=\u20093), and soft tissue (n\u2009=\u20093). Target lesions (n\u2009=\u200954) ranged in size from 1.5 to 2.5\u2009cm (median, 2\u2009cm). Treatment was well tolerated. After 2 months, an objective response was observed in 12\/19 (63%) patients, complete in 8 (42%). One\u2010year LPFS within treatment field was 68%. Local symptom improvement included palliation of bleeding (5\/19 patients) and pain relief (6\/19 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Electrochemotherapy may represent a new locoregional treatment for selected patients with superficial angiosarcomas. <jats:italic>J. Surg. Oncol. 2016;114:246\u2013253<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24287","type":"journal-article","created":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T06:00:29Z","timestamp":1462773629000},"page":"246-253","source":"Crossref","is-referenced-by-count":33,"title":["Local treatment with electrochemotherapy of superficial angiosarcomas: Efficacy and safety results from a multi\u2010institutional retrospective study"],"prefix":"10.1002","volume":"114","author":[{"given":"Michele","family":"Guida","sequence":"first","affiliation":[{"name":"Medical Oncology Unit Istituto dei Tumori Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca G.","family":"Campana","sequence":"additional","affiliation":[{"name":"Veneto Institute of Oncology IOV\u2010IRCCS Padova Italy"},{"name":"Department of Surgery, Oncology and Gastroenterology University of Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Curatolo","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery La Sapienza University Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabino","family":"Strippoli","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit Istituto dei Tumori Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Bonadies","sequence":"additional","affiliation":[{"name":"Plastic Surgery Unit San Gallicano Dermatologic Institute IRCCS IFO Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gretha","family":"Grilz","sequence":"additional","affiliation":[{"name":"Breast Surgery Unit Citt\u00e0 della salute e della scienza di Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Cabula","sequence":"additional","affiliation":[{"name":"Oncologic Surgery Ospedale Oncologico A. 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