{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:01:36Z","timestamp":1789668096599,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T00:00:00Z","timestamp":1464566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Cancer Institute, Bethesda, MD","award":["P30 CA16058"],"award-info":[{"award-number":["P30 CA16058"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The purpose of this study was to determine the pattern and timing of major wound complications (MWCs) in patients at our institution who received multimodality treatment for lower extremity soft tissue sarcoma (LE\u2010STS) and to evaluate the impact of MWCs on tumor control and patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of 102 LE\u2010STS patients treated with limb\u2010sparing surgery and radiation therapy were reviewed. MWCs were defined as secondary operations with anesthesia, seroma\/hematoma aspiration, admission for IV antibiotics, or persistent deep packing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MWCs occurred in 22% of patients, with 45% of events occurring &gt;120 days after resection. On multivariate analysis, preoperative external beam radiation therapy (EBRT) (OR 4.29, 95% CI 1.06\u201317.40, <jats:italic>P<\/jats:italic>\u2009=\u20090.042) and skin graft placement (OR 6.39, 95% CI 1.37\u201329.84, <jats:italic>P<\/jats:italic>\u2009=\u20090.018) were found to be independent predictors of MWCs. MWC occurrence did not predict for chronic toxicity and did not impact tumor control or survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A considerable proportion of MWCs occur &gt;120 days from surgical resection with preoperative EBRT and skin graft placement independent predictors for MWCs. While an additional source of morbidity, MWC occurrence did not impact tumor control, nor did it predict for chronic toxicity. <jats:italic>J. Surg. Oncol. 2016;114:385\u2013391<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24313","type":"journal-article","created":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T05:16:43Z","timestamp":1464585403000},"page":"385-391","source":"Crossref","is-referenced-by-count":30,"title":["Patterns of major wound complications following multidisciplinary therapy for lower extremity soft tissue sarcoma"],"prefix":"10.1002","volume":"114","author":[{"given":"Eric D.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokui","family":"Mo","sequence":"additional","affiliation":[{"name":"Center for Biostatistics The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole T.","family":"Andonian","sequence":"additional","affiliation":[{"name":"Department 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H.","family":"Iwenofu","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab","family":"Chakravarti","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Scharschmidt","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel L.","family":"Mayerson","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael E.","family":"Pollock","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and the Comprehensive Cancer Center The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xu\u2010Welliver","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09292-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"819s","DOI":"10.1200\/jco.2004.22.90140.9007","article-title":"Five\u2010year results of a randomized phase III trial of pre\u2010operative vs postoperative radiotherapy in extremity soft tissue sarcoma","volume":"22","author":"O'Sullivan B","year":"2004","journal-title":"J Clin 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