{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:57:42Z","timestamp":1775797062624,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Surg. Oncol."],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1002\/jso.24425","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T13:57:18Z","timestamp":1477663038000},"page":"803-809","source":"Crossref","is-referenced-by-count":75,"title":["The prognostic implications of primary colorectal tumor location on recurrence and overall survival in patients undergoing resection for colorectal liver metastasis"],"prefix":"10.1002","volume":"114","author":[{"given":"Kazunari","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Surgery; Johns Hopkins University School of Medicine; Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Andreatos","sequence":"additional","affiliation":[{"name":"Department of Surgery; Johns Hopkins University School of Medicine; Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios A.","family":"Margonis","sequence":"additional","affiliation":[{"name":"Department of Surgery; Johns Hopkins University School of Medicine; Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Surgery; Johns Hopkins University School of Medicine; Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Surgery; Johns Hopkins University School of Medicine; Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Surgery; Johns Hopkins University School of Medicine; Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Wolfgang","sequence":"additional","affiliation":[{"name":"Department of Surgery; Johns Hopkins University School of Medicine; Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstathios","family":"Antoniou","sequence":"additional","affiliation":[{"name":"Second; Department of Propaedeutic Surgery; Laiko Hospital; University of Athens; Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanouil","family":"Pikoulis","sequence":"additional","affiliation":[{"name":"First Department of Surgery; Laiko Hospital; University of Athens; Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy M.","family":"Pawlik","sequence":"additional","affiliation":[{"name":"Department of Surgery; Johns Hopkins University School of Medicine; Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,28]]},"reference":[{"key":"10.1002\/jso.24425-BIB0001|jso24425-cit-0001","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/DCR.0b013e3181c703a4","article-title":"Comparison of 17,641 patients with right- and left-sided colon cancer: Differences in epidemiology, perioperative course, histology, and survival","volume":"53","author":"Benedix","year":"2010","journal-title":"Dis Colon Rectum"},{"key":"10.1002\/jso.24425-BIB0002|jso24425-cit-0002","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1245\/s10434-008-0015-y","article-title":"Is there a difference in survival between right- versus left-sided colon cancers","volume":"15","author":"Meguid","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"10.1002\/jso.24425-BIB0003|jso24425-cit-0003","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/s11605-015-3026-6","article-title":"The worse prognosis of right-sided compared with left-sided colon cancers: A systematic review and meta-analysis","volume":"20","author":"Yahagi","year":"2016","journal-title":"J Gastrointest Surg"},{"key":"10.1002\/jso.24425-BIB0004|jso24425-cit-0004","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/jso.20156","article-title":"Two colons-two cancers: Paradigm shift and clinical implications","volume":"88","author":"Gervaz","year":"2004","journal-title":"J Surg Oncol"},{"key":"10.1002\/jso.24425-BIB0005|jso24425-cit-0005","doi-asserted-by":"crossref","first-page":"6470","DOI":"10.3748\/wjg.v21.i21.6470","article-title":"Different treatment strategies and molecular features between right-sided and left-sided colon cancers","volume":"21","author":"Shen","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1002\/jso.24425-BIB0006|jso24425-cit-0006","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ejso.2014.11.001","article-title":"Is right-sided colon cancer different to left-sided colorectal cancer?-A systematic review","volume":"41","author":"Lee","year":"2015","journal-title":"Eur J Surg Oncol"},{"key":"10.1002\/jso.24425-BIB0007|jso24425-cit-0007","doi-asserted-by":"crossref","first-page":"779","DOI":"10.7326\/0003-4819-113-10-779","article-title":"Colorectal cancer: Evidence for distinct genetic categories based on proximal or distal tumor location","volume":"113","author":"Bufill","year":"1990","journal-title":"Ann Intern Med"},{"key":"10.1002\/jso.24425-BIB0008|jso24425-cit-0008","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000443644","article-title":"Right sided colon cancer as a distinct histopathological subtype with reduced prognosis","volume":"33","author":"Nitsche","year":"2016","journal-title":"Dig Surg"},{"key":"10.1002\/jso.24425-BIB0009|jso24425-cit-0009","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/jamasurg.2015.0313","article-title":"Association between specific mutations in KRAS codon 12 and colorectal liver metastasis","volume":"150","author":"Margonis","year":"2015","journal-title":"JAMA Surg"},{"key":"10.1002\/jso.24425-BIB0010|jso24425-cit-0010","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1002\/cncr.30085","article-title":"Codon 13 KRAS mutation predicts patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases","volume":"122","author":"Margonis","year":"2016","journal-title":"Cancer"},{"key":"10.1002\/jso.24425-BIB0011|jso24425-cit-0011","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/SLA.0b013e3181b4539b","article-title":"Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: An international multi-institutional analysis of 1669 patients","volume":"250","author":"de Jong","year":"2009","journal-title":"Ann Surg"},{"key":"10.1002\/jso.24425-BIB0012|jso24425-cit-0012","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/jso.23756","article-title":"Overall survival by pattern of recurrence following curative intent surgery for colorectal liver metastasis","volume":"110","author":"Kulaylat","year":"2014","journal-title":"J Surg Oncol"},{"key":"10.1002\/jso.24425-BIB0013|jso24425-cit-0013","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00000658-199909000-00004","article-title":"Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: Analysis of 1001 consecutive cases","volume":"230","author":"Fong","year":"1999","journal-title":"Ann Surg"},{"key":"10.1002\/jso.24425-BIB0014|jso24425-cit-0014","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11912-007-0021-4","article-title":"Shifting from clinical to biologic indicators of prognosis after resection of hepatic colorectal metastases","volume":"9","author":"Pawlik","year":"2007","journal-title":"Curr Oncol Rep"},{"key":"10.1002\/jso.24425-BIB0015|jso24425-cit-0015","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/bjs.9870","article-title":"Meta-analysis of KRAS mutations and survival after resection of colorectal liver metastases","volume":"102","author":"Brudvik","year":"2015","journal-title":"Br J Surg"},{"key":"10.1002\/jso.24425-BIB0016|jso24425-cit-0016","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1093\/annonc\/mdu275","article-title":"Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features","volume":"25","author":"Missiaglia","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1002\/jso.24425-BIB0017|jso24425-cit-0017","doi-asserted-by":"crossref","first-page":"e78709","DOI":"10.1371\/journal.pone.0078709","article-title":"Differences in survival between colon and rectal cancer from SEER data","volume":"8","author":"Lee","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1002\/jso.24425-BIB0018|jso24425-cit-0018","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ijc.10635","article-title":"Are there two sides to colorectal cancer","volume":"101","author":"Iacopetta","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1002\/jso.24425-BIB0019|jso24425-cit-0019","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1245\/ASO.2005.01.010","article-title":"Hepatic and extrahepatic colorectal metastases: When resectable, their localization does not matter, but their total number has a prognostic effect","volume":"12","author":"Elias","year":"2005","journal-title":"Ann Surg Oncol"},{"key":"10.1002\/jso.24425-BIB0020|jso24425-cit-0020","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/PAS.0b013e31824430d7","article-title":"BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: An aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic features","volume":"36","author":"Pai","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1002\/jso.24425-BIB0021|jso24425-cit-0021","doi-asserted-by":"crossref","first-page":"18678","DOI":"10.1038\/srep18678","article-title":"Molecular spectrum of KRAS, NRAS, BRAF and PIK3CA mutations in Chinese colorectal cancer patients: Analysis of 1,110 cases","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci Rep"},{"key":"10.1002\/jso.24425-BIB0022|jso24425-cit-0022","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/(SICI)1097-0215(19971219)74:6<664::AID-IJC18>3.0.CO;2-5","article-title":"Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors","volume":"74","author":"Breivik","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1002\/jso.24425-BIB0023|jso24425-cit-0023","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3892\/mco.2014.448","article-title":"Association between specific KRAS mutations and the clinicopathological characteristics of colorectal tumors","volume":"3","author":"Kodaz","year":"2015","journal-title":"Mol Clin Oncol"},{"key":"10.1002\/jso.24425-BIB0024|jso24425-cit-0024","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.ejca.2015.03.015","article-title":"Location of colon cancer (right-sided versus left-sided) as a prognostic factor and a predictor of benefit from cetuximab in NCIC CO.17","volume":"51","author":"Brule","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1002\/jso.24425-BIB0025|jso24425-cit-0025","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1158\/1078-0432.CCR-13-3140","article-title":"KRAS codon 12 and 13 mutations in relation to disease-free survival in BRAF-wild-type stage III colon cancers from an adjuvant chemotherapy trial (N0147 alliance)","volume":"20","author":"Yoon","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1002\/jso.24425-BIB0026|jso24425-cit-0026","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1200\/JCO.2009.23.3452","article-title":"Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial","volume":"28","author":"Roth","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1002\/jso.24425-BIB0027|jso24425-cit-0027","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1002\/cncr.28347","article-title":"Incidence and prognostic impact of KRAS and BRAF mutation in patients undergoing liver surgery for colorectal metastases","volume":"119","author":"Karagkounis","year":"2013","journal-title":"Cancer"},{"key":"10.1002\/jso.24425-BIB0028|jso24425-cit-0028","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00534-012-0531-9","article-title":"Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability","volume":"20","author":"Umeda","year":"2013","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1002\/jso.24425-BIB0029|jso24425-cit-0029","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1038\/bjc.2015.142","article-title":"BRAF and RAS mutations as prognostic factors in metastatic colorectal cancer patients undergoing liver resection","volume":"112","author":"Schirripa","year":"2015","journal-title":"Br J Cancer"},{"key":"10.1002\/jso.24425-BIB0030|jso24425-cit-0030","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1002\/cncr.26086","article-title":"Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer","volume":"117","author":"Tran","year":"2011","journal-title":"Cancer"},{"key":"10.1002\/jso.24425-BIB0031|jso24425-cit-0031","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/SLA.0b013e3182a5025a","article-title":"RAS mutation status predicts survival and patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases","volume":"258","author":"Vauthey","year":"2013","journal-title":"Ann Surg"},{"key":"10.1002\/jso.24425-BIB0032|jso24425-cit-0032","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1634\/theoncologist.2009-0233","article-title":"Prognostic and predictive biomarkers in resected colon cancer: Current status and future perspectives for integrating genomics into biomarker discovery","volume":"15","author":"Tejpar","year":"2010","journal-title":"Oncologist"},{"key":"10.1002\/jso.24425-BIB0033|jso24425-cit-0033","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju427","article-title":"Primary tumor location as a prognostic factor in metastatic colorectal cancer","volume":"107","author":"Loupakis","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/jso.24425-BIB0034|jso24425-cit-0034","first-page":"107","article-title":"RE: Primary tumor location as a prognostic factor in metastatic colorectal cancer","author":"van Erning","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/jso.24425-BIB0035|jso24425-cit-0035","unstructured":"2016"},{"key":"10.1002\/jso.24425-BIB0036|jso24425-cit-0036","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1200\/JCO.2013.48.9591","article-title":"Prognostic impact of deficient DNA mismatch repair in patients with stage III colon cancer from a randomized trial of FOLFOX-based adjuvant chemotherapy","volume":"31","author":"Sinicrope","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1002\/jso.24425-BIB0037|jso24425-cit-0037","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/CAD.0000000000000041","article-title":"Outcome of patients with metastatic colorectal cancer depends on the primary tumor site (midgut vs. hindgut): Analysis of the FIRE1-trial (FuFIRI or mIROX as first-line treatment)","volume":"25","author":"Modest","year":"2014","journal-title":"Anticancer Drugs"},{"key":"10.1002\/jso.24425-BIB0038|jso24425-cit-0038","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/s00432-014-1678-3","article-title":"Left-sided primary tumors are associated with favorable prognosis in patients with KRAS codon 12\/13 wild-type metastatic colorectal cancer treated with cetuximab plus chemotherapy: An analysis of the AIO KRK-0104 trial","volume":"140","author":"von Einem","year":"2014","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1002\/jso.24425-BIB0039|jso24425-cit-0039","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1093\/annonc\/mdt253","article-title":"Primary tumor location and bevacizumab effectiveness in patients with metastatic colorectal cancer","volume":"24","author":"Boisen","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1002\/jso.24425-BIB0040|jso24425-cit-0040","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/tpj.2014.40","article-title":"Genes involved in pericyte-driven tumor maturation predict treatment benefit of first-line FOLFIRI plus bevacizumab in patients with metastatic colorectal cancer","volume":"15","author":"Volz","year":"2015","journal-title":"Pharmacogenomics J"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.24425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.24425","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jso.24425\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T18:51:58Z","timestamp":1657565518000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.24425"}},"subtitle":["Primary CRC Location and CRLM Prognosis"],"short-title":[],"issued":{"date-parts":[[2016,10,28]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,12]]}},"URL":"https:\/\/doi.org\/10.1002\/jso.24425","archive":["Portico"],"relation":{},"ISSN":["0022-4790"],"issn-type":[{"value":"0022-4790","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10,28]]}}}