{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:00:05Z","timestamp":1790049605689,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T00:00:00Z","timestamp":1473984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with limited therapeutic options beyond surgical resection. The characteristics of actual long\u2010term survivors following surgical resection for ACC have not been previously reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients who underwent resection for ACC at one of 13 academic institutions participating in the US Adrenocortical Carcinoma Group from 1993 to 2014 were analyzed. Patients were stratified into four groups: early mortality (died within 2 years), late mortality (died within 2\u20135 years), actual 5\u2010year survivor (survived at least 5 years), and actual 10\u2010year survivor (survived at least 10 years). Patients with less than 5 years of follow\u2010up were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 180 patients available for analysis, there were 49 actual 5\u2010year survivors (27%) and 12 actual 10\u2010year survivors (7%). Patients who experienced early mortality had higher rates of cortisol\u2010secreting tumors, nodal metastasis, synchronous distant metastasis, and R1 or R2 resections (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The need for multi\u2010visceral resection, perioperative blood transfusion, and adjuvant therapy correlated with early mortality. However, nodal involvement, distant metastasis, and R1 resection did not preclude patients from becoming actual 10\u2010year survivors. Ten of twelve actual 10\u2010year survivors were women, and of the seven 10\u2010year survivors who experienced disease recurrence, five had undergone repeat surgery to resect the recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Surgery for ACC can offer a 1 in 4 chance of actual 5\u2010year survival and a 1 in 15 chance of actual 10\u2010year survival. Long\u2010term survival was often achieved with repeat resection for local or distant recurrence, further underscoring the important role of surgery in managing patients with ACC. <jats:italic>J. Surg. Oncol. 2016;114:971\u2013976<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24439","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T06:28:04Z","timestamp":1474007284000},"page":"971-976","source":"Crossref","is-referenced-by-count":39,"title":["Actual 10\u2010year survivors following resection of adrenocortical carcinoma"],"prefix":"10.1002","volume":"114","author":[{"given":"Thuy B.","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Surgery Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Postlewait","sequence":"additional","affiliation":[{"name":"Department of Surgery Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishir K.","family":"Maithel","sequence":"additional","affiliation":[{"name":"Department of Surgery Emory University 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