{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:07Z","timestamp":1786978267731,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T00:00:00Z","timestamp":1487808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000454"],"award-info":[{"award-number":["UL1TR000454"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Current data on the utility of port\u2010site excision (PSE) during re\u2010resection for incidentally discovered gallbladder cancer (IGBC) in the US are conflicting and limited to single\u2010institution series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>All patients with IGBC who underwent curative re\u2010resection at 10 institutions from 2000 to 2015 were included. Patients with and without PSE were compared. Primary outcome was overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Of 449\u2009pts with GBC, 266 were incidentally discovered, of which 193(73%) underwent curative re\u2010resection and had port\u2010site data; 47\u2009pts(24%) underwent PSE, 146(76%) did not. The PSE rate remained similar over time (2000\u20102004: 33%; 2005\u20102009: 22%; 2010\u20102015:22%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.36). Both groups had similar demographics, operative procedures, and post\u2010operative complications. There was no difference in T\u2010stage (T1: 9 vs. 11%; T2: 52 vs. 52%; T3: 39 vs. 38%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.96) or LN involvement (36 vs. 41%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.7) between groups. A 3\u2010year OS was similar between PSE and no PSE groups (65 vs. 43%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.07). On univariable analysis, residual disease at re\u2010resection (HR\u2009=\u20092.1, 95% CI 1.4\u20103.3;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001), high tumor grade, and advanced T\u2010stage were associated with decreased OS. Only grade and T\u2010stage, but not PSE, persisted on multivariable analysis. Distant disease recurrence\u2010rate was identical between PSE and no PSE groups (80 vs. 81%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20091.0).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Port\u2010site excision during re\u2010resection for IGBC is not associated with improved overall survival and has the same distant disease recurrence compared to no port\u2010site excision. Routine port\u2010site excision is not recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.24591","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T08:08:16Z","timestamp":1487837296000},"page":"805-811","source":"Crossref","is-referenced-by-count":37,"title":["Routine port\u2010site excision in incidentally discovered gallbladder cancer is not associated with improved survival: A multi\u2010institution analysis from the US Extrahepatic Biliary Malignancy Consortium"],"prefix":"10.1002","volume":"115","author":[{"given":"Cecilia G.","family":"Ethun","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Postlewait","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Le","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Pawlik","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery The Johns Hopkins Hospital Baltimore Maryland"},{"name":"Division of Surgical Oncology The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Poultsides","sequence":"additional","affiliation":[{"name":"Department of Surgery Stanford University Medical Center Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Surgery Stanford University Medical Center Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Idrees","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery Vanderbilt University Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea A.","family":"Isom","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery Vanderbilt University Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C.","family":"Fields","sequence":"additional","affiliation":[{"name":"Department of Surgery Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Krasnick","sequence":"additional","affiliation":[{"name":"Department of Surgery Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Wisconsin School of Medicine and Public Health Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Wisconsin School of Medicine and Public Health Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C. G.","family":"Martin","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery University of Louisville Louisville Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Scoggins","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery University of Louisville Louisville Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Surgery Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harveshp D.","family":"Mogal","sequence":"additional","affiliation":[{"name":"Department of Surgery Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza","family":"Beal","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Hatzaras","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rivfka","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Cardona","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishir K.","family":"Maithel","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery Winship Cancer Institute Emory University Atlanta 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