{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:42:00Z","timestamp":1761709320590,"version":"3.37.3"},"reference-count":79,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:label\/><jats:p>The essential diagnosis for LAPC is based on high\u2010quality cross\u2010sectional imaging, which demonstrates tumor invasion into the celiac\/superior mesenteric arteries and\/or superior mesenteric\/portal venous system that is not reconstructable. The optimal management of these patients is evolving quickly with the advent of newer chemotherapeutics, radiation, and non\u2010thermal ablation modalities. This review will present the current status of initial chemotherapy, surgical therapy, ablative therapy, and radiation therapy for patients with nonmetastatic locally advanced unresectable pancreatic cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24640","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T17:22:39Z","timestamp":1494004959000},"page":"35-45","source":"Crossref","is-referenced-by-count":8,"title":["Multi\u2010disciplinary management of locally advanced pancreatic cancer with irreversible electroporation"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5537-3387","authenticated-orcid":false,"suffix":"II","given":"Robert C.G.","family":"Martin","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery, University of Louisville Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,5]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"486","article-title":"Long\u2010term survival in metastatic pancreatic cancer. A case report and review of the literature","volume":"7","author":"Spinelli GP","year":"2006","journal-title":"JOP"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.52.1.23"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0408-6"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.08.011"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900603"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-4-11"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.8904"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011923"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.5663"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2016.07.010"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2004.09.026"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-004-8165-x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13131184"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4225-1"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011923"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304369"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds224"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2001.49281.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-013-2443-7"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.112"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.12.082"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq011"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2110-8"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3486-z"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.2690"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000867"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)00172-8"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.06.058"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001441"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23392"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-013-2309-z"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.07.048"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.07.002"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-010-1323-7"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24059"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.01.051"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603719"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.12.074"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.7921"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.5663"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22735"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26633"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2011.152"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9032-x"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2009.06.005"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10148"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2005.10.034"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.3156804"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1006\/cryo.2001.2312"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-006-0098-5"},{"key":"e_1_2_5_52_1","first-page":"588","article-title":"Radiofrequency ablation of the pancreas. II: Intra\u2010operative ablation of non\u2010resectable pancreatic cancer. A description of technique and initial outcome","volume":"6","author":"Date RS","year":"2005","journal-title":"JOP"},{"key":"e_1_2_5_53_1","first-page":"1","article-title":"Radiofrequency ablation for locally advanced cancer of the pancreas","volume":"7","author":"Siriwardena AK","year":"2006","journal-title":"JOP"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21899"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.v35.i1-2.20"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2010.00174.x"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2012.05.021"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24404"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9536"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-005-8981-8"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001135"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheatmasstransfer.2008.04.041"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009344984"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652306776359504"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1363.007"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-005-8981-8"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/153303460700600106"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2006.873745"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1177\/153303460700600407"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.10.013"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2736-1"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9536"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2012.09.012"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-9632-8_23"},{"key":"e_1_2_5_75_1","first-page":"329","article-title":"Irreversible electroporation of locally advanced pancreatic neck\/body adenocarcinoma","volume":"6","author":"Martin RC","year":"2015","journal-title":"J Gastrointest Oncol"},{"key":"e_1_2_5_76_1","first-page":"211","article-title":"Use of irreversible electroporation in unresectable pancreatic cancer","volume":"4","author":"Martin RC","year":"2015","journal-title":"Hepatobiliary Surg Nutr"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076260"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/680319"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-016-0815-7"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24288"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.24640","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.24640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:50:57Z","timestamp":1696398657000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.24640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,5]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/jso.24640"],"URL":"https:\/\/doi.org\/10.1002\/jso.24640","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"type":"print","value":"0022-4790"},{"type":"electronic","value":"1096-9098"}],"subject":[],"published":{"date-parts":[[2017,5,5]]}}}