{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:32:53Z","timestamp":1760189573281,"version":"3.37.3"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["UL1\u2010TR\u2010001857"],"award-info":[{"award-number":["UL1\u2010TR\u2010001857"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The role of hyperthermic intraperitoneal chemoperfusion (HIPEC) in the multimodality treatment of ovarian peritoneal metastases (OPM) and primary peritoneal cancer (PPC) remains controversial. We hypothesized that cytoreductive surgery (CRS) and HIPEC would provide meaningful survival benefit without excessive morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed clinicopathologic and perioperative data following 96 CRS\u2010HIPEC procedures for primary or recurrent OPM and PPC. Kaplan\u2010Meier survival curves and multivariate Cox\u2010regression models identified prognostic factors affecting oncologic outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CRS\u2010HIPEC was mostly performed for recurrent disease (56.3%) and high\u2010grade serous carcinoma (72.9%). Platinum\u2010based systemic chemotherapy was administered to 89.5% of patients, with 75.5% having platinum\u2010sensitive disease at CRS\u2010HIPEC. Complete macroscopic resection was achieved in 70.8% of patients. Clavien\u2010Dindo grade 3\/4 morbidity occurred in 23.4% of patients; three patients died within 60\u2010days postoperatively. Median overall survival from diagnosis of peritoneal metastases and CRS\u2010HIPEC was 78 and 38 months, respectively. Completeness of cytoreduction, pathologic subtype, and 30\u2010day morbidity were independent predictors of survival in multiple regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrates promising survival data and supports the role of HIPEC in the multimodality treatment algorithm for primary or recurrent OPM and PPC. However definite indications and timing of HIPEC need to be clarified by prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24666","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T20:12:43Z","timestamp":1497903163000},"page":"320-328","source":"Crossref","is-referenced-by-count":11,"title":["Hyperthermic intraperitoneal chemoperfusion as a component of multimodality therapy for ovarian and primary peritoneal cancer"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0791-4505","authenticated-orcid":false,"given":"Deepa","family":"Magge","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, Koch Regional Perfusion Center University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lekshmi","family":"Ramalingam","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Koch Regional Perfusion Center University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongli","family":"Shuai","sequence":"additional","affiliation":[{"name":"The University of Pittsburgh Cancer Institute Biostatistics Facility Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Koch Regional Perfusion Center University of Pittsburgh Pittsburgh Pennsylvania"},{"name":"Department of Obstetrics and Gynecology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Pingpank","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Koch Regional Perfusion Center University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven S.","family":"Ahrendt","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Koch Regional Perfusion Center University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P.","family":"Holtzman","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Koch Regional Perfusion Center University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert J.","family":"Zeh","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Koch Regional Perfusion Center University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Koch Regional Perfusion Center University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haroon A.","family":"Choudry","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Koch Regional Perfusion Center University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61338-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041842"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.153"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199612263352603"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052985"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.4.1001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.9898"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.5.1248"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.224"},{"key":"e_1_2_8_12_1","first-page":"CD005340","article-title":"Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer","volume":"2006","author":"Jaaback K","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp151"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70539-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.1142"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.9640"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.1.1.142"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2010.09.002"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviscsurg.2014.07.005"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.11.072"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2015.26.1.54"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.05.004"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181c50cde"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161212802002616"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.08.033"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.328"},{"key":"e_1_2_8_27_1","first-page":"10","article-title":"Hyperthermic intraperitoneal chemotherapy for epithelial ovarian cancers: is there a role","volume":"7","author":"Boisen MM","year":"2016","journal-title":"J Gastrointest Oncol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.09.020"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.04.008"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4157-9"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1247-5_23"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e3181a9c6f0"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e31821bb8aa"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24149"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00278-6"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.03.018"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt333"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v2.i2.68"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0558-6"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.08.011"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908806"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62223-6"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.09.002"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.01.009"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.07.004"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2013.09.030"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.313105066"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.80"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980915)83:6<1251::AID-CNCR27>3.0.CO;2-3"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.05.032"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29011"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.24666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.24666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:40:26Z","timestamp":1696398026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.24666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,19]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1002\/jso.24666"],"URL":"https:\/\/doi.org\/10.1002\/jso.24666","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"type":"print","value":"0022-4790"},{"type":"electronic","value":"1096-9098"}],"subject":[],"published":{"date-parts":[[2017,6,19]]}}}