{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:05:07Z","timestamp":1786705507927,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T00:00:00Z","timestamp":1497225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007154","name":"Wake Forest University","doi-asserted-by":"publisher","award":["NCI CCSG P30CA012197"],"award-info":[{"award-number":["NCI CCSG P30CA012197"]}],"id":[{"id":"10.13039\/100007154","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Repeat cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS\/HIPEC) for recurrence of peritoneal surface malignancies is safe and effective. Patient selection and factors associated with a favorable outcome are still evolving.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospectively maintained institutional database consisting of 1314 CRS\/HIPEC procedures performed between February 1993 and December 2015 was reviewed. Clinicopathologic data from 103 patients and 112 (8.5%) repeat CRS\/HIPEC procedures were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Primary tumors were appendiceal for 60 patients (58.3%), mesothelioma for 14 (13.6%), colorectal for 9 (8.7%), ovarian for 8 (7.8%). R0\/R1 resection was achieved in 46 (46.5%) patients. The time interval between the initial and the repeat CRS\/HIPEC was &lt;1 year for 21 (20.4%), 1\u20102 years for 40 (38.8%), and &gt;2 years for 42 patients (40.8%). Overall median survival was 4.3 years and correlated with the time interval (1.3 years for &lt;1 years, 3.7 years for 1\u20102 years, and 7 years for &gt;2 years; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In multivariate analysis, the R status (<jats:italic>P<\/jats:italic>\u2009=\u20090.005) and a time interval of more than 2 years (<jats:italic>P<\/jats:italic>\u2009=\u20090.0002) were strongly associated with survival with each additional month between the surgeries conferring a 2.6% reduction in the risk of death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current series validates time interval between cytoreductions as a major surrogate of tumor biology in selection of patients with recurrent peritoneal surface malignancies for repeat CRS\/HIPEC. Complete repeat cytoreduction more than 2 years from the initial surgery is associated with a favorable outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24703","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T04:06:40Z","timestamp":1497326800000},"page":"741-745","source":"Crossref","is-referenced-by-count":26,"title":["Interval between cytoreductions as a marker of tumor biology in selecting patients for repeat cytoreductive surgery with hyperthermic intraperitoneal chemotherapy"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-356X","authenticated-orcid":false,"given":"Ioannis T.","family":"Konstantinidis","sequence":"first","affiliation":[{"name":"Surgical Oncology Service Department ofGeneral Surgery, City of Hope Cancer Center Duarte CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Levine","sequence":"additional","affiliation":[{"name":"Surgical Oncology Service Department of General Surgery, City of Hope Cancer Center Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Chouliaras","sequence":"additional","affiliation":[{"name":"Surgical Oncology Service Department of General Surgery, City of Hope Cancer Center Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry","family":"Shen","sequence":"additional","affiliation":[{"name":"Surgical Oncology Service Department of General Surgery, City of Hope Cancer Center Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos I.","family":"Votanopoulos","sequence":"additional","affiliation":[{"name":"Surgical Oncology Service Department of General Surgery, City of Hope Cancer Center Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.12.013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-9966-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9182-x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.7166"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2004.08.014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2012.04.023"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-015-2986-8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23062"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.24703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.24703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T11:59:58Z","timestamp":1695643198000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.24703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,12]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/jso.24703"],"URL":"https:\/\/doi.org\/10.1002\/jso.24703","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,12]]}}}