{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:50:44Z","timestamp":1790013044365,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foundation Against Cancer and the National Institute for Disease and Invalidity Assurance"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In rectal cancer, the significance of abdominopelvic sepsis (APS) on metastatic tumor growth remains uncertain. We aimed to analyze the effect of abdominopelvic sepsis on long\u2010term survival in patients undergoing restorative rectal cancer surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were used from the Belgian PROCARE rectal cancer registry. The effect of abdominopelvic infection on survival was assessed in uni\u2010 and multivariable Cox regression models. The effect of clinical and pathological covariates was controlled by propensity score\u2010based matching of cases with controls. The effect of abdominopelvic sepsis on the rate of local and metastatic recurrence was evaluated using crosstabulation and the Pearson <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In univariable analysis, the presence of APS was associated with significantly worse overall survival (HR 1.3, <jats:italic>P<\/jats:italic>\u2009=\u20090.025). After propensity score matching including age, BMI, tumor level, pTstage, pN stage, CRM, tumor grade, number of lymph nodes, and presence of lymphovascular invasion, the association of APS with OS was no longer significant (HR 1.26, 95%CI 0.92\u20101.74, <jats:italic>P<\/jats:italic>\u2009=\u20090.15). No differences were observed in the risk of local or metastatic recurrence (3.6% vs 2.9% and 13% vs 16.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this analysis APS after rectal cancer resection was not significantly associated with OS, metastatic, or local recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24706","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T20:22:44Z","timestamp":1497903764000},"page":"722-729","source":"Crossref","is-referenced-by-count":6,"title":["Effect of abdominopelvic sepsis on cancer outcome in patients undergoing sphincter saving surgery for rectal cancer"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7068-9518","authenticated-orcid":false,"given":"Dirk","family":"Van de putte","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery Ghent University Hospital Ghent 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