{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:03:34Z","timestamp":1779217414408,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T00:00:00Z","timestamp":1498435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>Background and Objectives To present treatment outcomes and prognostic factors for surgical management of locally advanced differentiated thyroid cancer (DTC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of 70 patients in a single, tertiary referral institution was done. Clinical pathology characteristics were analyzed to investigate prognosticators, based on primary endpoints; locoregional recurrence alone (LRR), total recurrence (LRR or distant metastasis (DM)), and recurrence\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recurrent laryngeal nerve (<jats:italic>n<\/jats:italic>\u2009=\u200931) and trachea (<jats:italic>n<\/jats:italic>\u2009=\u200930) were most commonly invaded organs by tumor. At the mean follow\u2010up of 81.7 months, LRR occurred in 15 patients and\/or DM was detected in 15 patients (10 developed LRR and DM). By multivariate analysis, R1 resection (positive margin) and pN1b stage increased risk of LRR with a fold of 3.16 [95%CI 1.08\u20109.24, <jats:italic>P<\/jats:italic>\u2009=\u20090.03] and 5.92 [1.61\u201021.7, <jats:italic>P<\/jats:italic>\u2009=\u20090.007], respectively. Also, they increased risk of total recurrence with a fold of 3.04 [95%CI 1.26\u20107.31, <jats:italic>P<\/jats:italic>\u2009=\u20090.01] and 3.42 [95%CI 1.16\u201010.0, <jats:italic>P<\/jats:italic>\u2009=\u20090.02], respectively. Patients with pN1b stage showed better LRR\u2010free survival than pN0\/N1a stage (<jats:italic>P<\/jats:italic>\u2009=\u20090.03).<\/jats:p><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Along with careful preoperative evaluation of the extent of primary and neck disease, obtaining negative resection margin and aggressive neck management is critical to improve oncologic outcomes of locally advanced DTC.<\/jats:p><\/jats:sec><\/jats:sec>","DOI":"10.1002\/jso.24740","type":"journal-article","created":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T14:14:41Z","timestamp":1498486481000},"page":"877-883","source":"Crossref","is-referenced-by-count":17,"title":["Prognostic factors for recurrence of locally advanced differentiated thyroid cancer"],"prefix":"10.1002","volume":"116","author":[{"given":"Bo\u2010Young","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Eun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunkyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Ik","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Hwan","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1435-7786","authenticated-orcid":false,"given":"Man Ki","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of 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