{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:56:16Z","timestamp":1783389376944,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T00:00:00Z","timestamp":1498435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Nodal recurrence following negative sentinel lymph node biopsy (SLNB) for melanoma is known as false\u2010negative (FN) SLNB. Risk factors for FN SLNB among patients with trunk and extremity melanoma have not been well\u2010defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After retrospective review, SLNB procedures were classified FN, true positive (TP; positive SLNB), or true negative (TN; negative SLNB without recurrence). Factors associated with high false negative rate (FNR) and low negative predictive value (NPV) were identified by comparing FNs to TPs and TNs, respectively. Survival was evaluated using Kaplan\u2010Meier methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1728 patients, 234 were TP and 37 were FN for overall FNR of 14% and NPV of 97.5%. Age \u226565 years was independently associated with high FNR (FNR 20% in this group). Breslow thickness &gt;1\u2009mm and ulceration were independently associated with low NPV. Among patients with ulcerated tumors &gt;4\u2009mm, NPV was 88%. Median time to recurrence for FNs was 13 months. Among patients with primary melanomas \u22642\u2009mm in depth, overall and distant disease\u2010free survival were significantly shorter with FN SLNB than TP SLNB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Older age is associated with increased FNR; patients with thick, ulcerated lesions should be considered for increased nodal surveillance after negative SLNB given low NPV in this group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24743","type":"journal-article","created":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T14:20:43Z","timestamp":1498486843000},"page":"848-855","source":"Crossref","is-referenced-by-count":31,"title":["Predictors of false negative sentinel lymph node biopsy in trunk and extremity melanoma"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6031-6451","authenticated-orcid":false,"given":"Andrew J.","family":"Sinnamon","sequence":"first","affiliation":[{"name":"Department of Surgery University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madalyn G.","family":"Neuwirth","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund K.","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Zaheer","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Etherington","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Elder","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Czerniecki","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas L.","family":"Fraker","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgos 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