{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T18:56:14Z","timestamp":1780685774898,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T00:00:00Z","timestamp":1498435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>We investigated the risk factors, incidence, and role of thromboprophylaxis in the development of thrombosis following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS\/HIPEC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed data of patients with CRS\/HIPEC in three hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 192 patients underwent CRS\/HIPEC during 2007\u20102016. Mechanical (thigh\u2010length pneumatic compression stockings) and pharmacologic thromboprophylaxis (40\u2009mg enoxaparin daily, starting 12\u2009h before surgery until discharge) was provided for all patients; and 116 (60.4%) also received an extended course of enoxaparin for 2\u20104 weeks after discharge. Twenty\u2010six patients experienced thrombotic complications (13.5%) including portal\u2010splenic\u2010mesenteric venous thrombosis (<jats:italic>n<\/jats:italic>\u2009=\u200911, 5.7%), pulmonary embolism (<jats:italic>n<\/jats:italic>\u2009=\u200910, 5.2%), and deep vein thrombosis (<jats:italic>n<\/jats:italic>\u2009=\u20095, 2.6%); most (<jats:italic>n<\/jats:italic>\u2009=\u200921, 80.8%) occurred after hospital discharge. Univariate analysis identified Peritoneal Cancer Index, intraoperative transfusion requirement, operative blood loss, operative time, lengths of hospital, and intensive care unit stay, and lack of administration of anticoagulation at discharge as significantly associated with thrombosis. With multivariate analysis, only the lack of anticoagulation therapy at discharge remained significantly associated with thrombosis (<jats:italic>P<\/jats:italic>\u2009=\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thromboembolic complications are common following CRS\/HIPEC. As significantly lower rates of thrombosis were found in patients who received an extended course of anticoagulation, we support its use for at least 2 weeks after discharge.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24746","type":"journal-article","created":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T14:14:34Z","timestamp":1498486474000},"page":"914-920","source":"Crossref","is-referenced-by-count":24,"title":["Factors associated with thromboembolic events following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy"],"prefix":"10.1002","volume":"116","author":[{"given":"Amihai","family":"Rottenstreich","sequence":"first","affiliation":[{"name":"Department of Hematology Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9533-5775","authenticated-orcid":false,"given":"Yosef","family":"Kalish","sequence":"additional","affiliation":[{"name":"Department of Hematology Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geffen","family":"Kleinstern","sequence":"additional","affiliation":[{"name":"Braun School of Public Health and Community Medicine Faculty of Medicine of the Hebrew University and Hadassah Jerusalem Israel"},{"name":"Department of Health Sciences Research  Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almog Ben","family":"Yaacov","sequence":"additional","affiliation":[{"name":"Department of General and Oncological Surgery\u2010 Surgery C The Chaim Sheba Medical Center Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Dux","sequence":"additional","affiliation":[{"name":"Department of General and Oncological Surgery\u2010 Surgery C The Chaim Sheba Medical Center Ramat Gan 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