{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:58:13Z","timestamp":1760889493018,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>We excised cutaneous squamous cell carcinoma (cSCC) of the face while using intra\u2010operative frozen section analysis of the margins in an optimized bread\u2010loafing fashion (WIFSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records were reviewed of 160 cSCCs of the face that were treated by surgical excision with WIFSA between April 2007 and January 2013. The accuracy of WIFSA was verified by comparing results with postoperative formalin\u2010fixed paraffin\u2010embedded (FFPE) sections. Also, recurrence and metastasis during follow\u2010up were studied and duration of treatment and complications were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 160 cSCCs affected 152 patients. In 131 cSCCs (mean follow\u2010up: 41.0 months, SD: \u00b126.3, range: 3.0\u2010110.7) occurred 6 (4.6%) recurrences and 2 (1.5%) metastases. Of the WIFSA results, 98.8% corresponded with postoperative FFPE sections. Mean duration of treatment was 77\u2009min (SD: \u00b125, range: 34\u2010159) and complication rate was 8.1%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Surgical excision with WIFSA is an excellent treatment modality for cSCC of the face because of its accurate method for assessment of complete tumor removal, low recurrence and metastasis rate, short average duration of treatment, and low complication rate.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24870","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T21:36:37Z","timestamp":1509053797000},"page":"473-478","source":"Crossref","is-referenced-by-count":7,"title":["Effective excision of cutaneous squamous cell carcinoma of the face using analysis of intra\u2010operative frozen sections from the whole specimen"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4872-7693","authenticated-orcid":false,"given":"Kor H.","family":"Hutting","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Medisch Centrum Leeuwarden Leeuwarden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul G.","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Medisch Centrum Leeuwarden Leeuwarden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robby E.","family":"Kibbelaar","sequence":"additional","affiliation":[{"name":"Pathologie Friesland Leeuwarden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nic J. 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M.","family":"Veeger","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Medisch Centrum Leeuwarden Leeuwarden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaas W.","family":"Marck","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Medisch Centrum Leeuwarden Leeuwarden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal M.","family":"Mou\u00ebs","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Medisch Centrum Leeuwarden Leeuwarden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980529)76:5<628::AID-IJC3>3.0.CO;2-S"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.06.110"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.5858\/2005-129-1536-FSOSS","article-title":"Frozen section of skin specimens","volume":"129","author":"Smith\u2010Zagone MJ","year":"2005","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1976.01630260033010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12743"},{"key":"e_1_2_6_7_1","first-page":"1409","article-title":"Low 5\u2010year recurrence rate after surgical excision of 126 basal cell carcinomas with frozen section analysis upon indication","volume":"145","author":"Van der Meer GT","year":"2001","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.10.1161"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.03.055"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/00000637-199943020-00009","article-title":"Frozen section analysis in the management of skin cancers","volume":"43","author":"Ghauri RR","year":"1999","journal-title":"Ann Plast Surg"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.07.020"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.02.059"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2015.12.023"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23155"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1992.tb07065.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70144-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70178-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2012.51"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SAP.0000069073.38391.91"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2015.11.004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.2.187"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.6255"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70212-Z"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.24870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.24870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T07:42:15Z","timestamp":1695627735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.24870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,26]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/jso.24870"],"URL":"https:\/\/doi.org\/10.1002\/jso.24870","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"type":"print","value":"0022-4790"},{"type":"electronic","value":"1096-9098"}],"subject":[],"published":{"date-parts":[[2017,10,26]]}}}