{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:41:47Z","timestamp":1789681307085,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T00:00:00Z","timestamp":1508112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Stichting MelanomaSarcomaGroningana (Ubbergseveldweg 144, Nijmegen, The Netherlands)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Despite multimodality limb salvage treatment (LST) for locally advanced extremity soft tissue sarcoma (ESTS), some patients still need an amputation. Indications for amputation and oncological outcome for these patients are described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 1996 and 2016, all patients who underwent an amputation for ESTS were included. Patients who underwent an amputation as primary or as non\u2010primary treatment formed Group I and II, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine patients were included, 16 in Group I (41%) and 23 in Group II (59%). Tumor size or local recurrence which could not be treated with LST were the two main reasons for amputation. Local recurrence free survival (LRFS) (<jats:italic>P<\/jats:italic>\u2009=\u20090.396), distant metastases free survival (DMFS) (<jats:italic>P<\/jats:italic>\u2009=\u20090.965), disease\u2010specific survival (DSS) (<jats:italic>P<\/jats:italic>\u2009=\u20090.745), and overall survival (OS) (<jats:italic>P<\/jats:italic>\u2009=\u20090.718) were comparable for both groups. Ten\u2010year LRFS was 90.0% versus 83.7%; DMFS was 31.0% versus 42.2%; DSS was 52.2% versus 44.1%; and OS was 44.2% versus 41.6%, for group I and II respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oncological outcome seems to be comparable between patients who underwent a primary or a non\u2010primary amputation for ESTS. With the on\u2010going possibilities concerning prosthesis and rehabilitation programs, it remains important to decide in a multidisciplinary sarcoma team meeting which treatment suits best for each individual patient.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24881","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T20:07:10Z","timestamp":1508184430000},"page":"434-442","source":"Crossref","is-referenced-by-count":31,"title":["Amputations for extremity soft tissue sarcoma in an era of limb salvage treatment: Local control and survival"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9986-3505","authenticated-orcid":false,"given":"Marc G.","family":"Stevenson","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelie H.","family":"Musters","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.B.","family":"Geertzen","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara L.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald J.","family":"Hoekstra","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas B.","family":"Been","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_9_3_1","unstructured":"Soft Tissue Sarcoma incidence Nederlandse Kankerregistratie beheerd door IKNL \u00a9 [May] 2017 2016;2017."},{"key":"e_1_2_9_4_1","unstructured":"Soft Tissue Sarcoma deaths Nederlandse Kankerregistratie beheerd door IKNL \u00a9 [May] 2017 2016;2017."},{"key":"e_1_2_9_5_1","volume-title":"WHO Classification of Tumours of Soft Tissue and Bone","author":"Fletcher CDM","year":"2013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2012.08.024"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-7-15"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2003.11927915"},{"key":"e_1_2_9_9_1","first-page":"CD001419","article-title":"Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults. 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