{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:23:14Z","timestamp":1775143394247,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Elevated BNP is associated with adverse cardiac outcomes after noncardiac surgery. We assessed BNP values as markers of perioperative fluid status and their correlation with major\/cardiopulmonary (CP) complications following CRS\u2009+\u2009HIPEC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fluid balance, BNP levels, and morbidity data were collected for all patients undergoing CRS\u2009+\u2009HIPEC between 6\/2014 and 2\/2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and twenty\u2010nine patients underwent CRS\u2009+\u2009HIPEC for appendiceal adenocarcinoma (<jats:italic>n<\/jats:italic>\u2009=\u200999), mesothelioma (<jats:italic>n<\/jats:italic>\u2009=\u200916), and colon cancer (<jats:italic>n<\/jats:italic>\u2009=\u200914). Less than 10% had CP comorbidities. The median PCI was 14 (range 4\u201039); 89% underwent CC0\/1 resection (<jats:italic>n<\/jats:italic>\u2009=\u2009115). Median blood loss (EBL) was 497\u2009mL (50\u20102700). Major complications (Clavien III\u2010V) occurred in 16 (12%), CP in 17 (13%), and major\/CP in 24 (18%). Thirty\u2010day mortality occurred in 2 (1.5%). Elevated BNP on POD1 correlated with increased risk of major\/CP complications (OR 2.2, <jats:italic>P<\/jats:italic>\u2009=\u20090.052). This was most pronounced in the 25 patients receiving cisplatin: for each 100 unit increase in POD1 BNP the OR for major\/CP complication was 7.4 versus 1.2 for the remaining patients, <jats:italic>P<\/jats:italic>\u2009=\u20090.083. Multivariate analysis identified increased EBL (OR 4.1 <jats:italic>P<\/jats:italic>\u2009=\u20090.011) and a trend toward increased BNP on POD1 (OR for each 100 unit increase 2.0, <jats:italic>P<\/jats:italic>\u2009=\u20090.10) as risk factors for major\/CP complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Postoperative BNP measurement after CRS\u2009+\u2009HIPEC may guide postoperative fluid resuscitation and facilitate identification of patients at risk for major and\/or cardiopulmonary complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24904","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:22:05Z","timestamp":1511976125000},"page":"685-691","source":"Crossref","is-referenced-by-count":8,"title":["Elevated brain natriuretic peptide (BNP) is an early marker for patients at risk for complications after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS\u2009+\u2009HIPEC)"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-2633","authenticated-orcid":false,"given":"Sarah B.","family":"Fisher","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safia","family":"Rafeeq","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Hess","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7753-097X","authenticated-orcid":false,"given":"Travis E.","family":"Grotz","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Mansfield","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Royal","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Badgwell","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Fleming","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Fournier","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary N.","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Surgery Arnot Ogden Medical Center Elmira New 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