{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:41:05Z","timestamp":1788327665555,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T00:00:00Z","timestamp":1512000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Indications for sentinel lymph node (SLN) biopsy in patients with thin melanoma (\u22641\u2009mm thick) are controversial. We asked whether deep margin (DM) positivity at initial biopsy of thin melanoma is associated with SLN positivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases were identified using prospectively maintained databases at two melanoma centers. Patients who had undergone SLN biopsy for melanoma \u22641\u2009mm were included. DM status was assessed for association with SLN metastasis in univariate and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>1413 cases were identified, but only 1129 with known DM status were included. 39% of patients had a positive DM on original biopsy. DM\u2010positive and DM\u2010negative patients did not differ significantly in primary thickness, ulceration, or mitotic activity. DM\u2010positive and DM\u2010negative patients had similar incidence of SLN metastasis (5.7% vs 3.5%; <jats:italic>P<\/jats:italic>\u2009=\u20090.07). Positive DM was not associated with SLN metastasis on univariate analysis (OR 1.69, 95% CI: 0.95\u20103.00, <jats:italic>P<\/jats:italic>\u2009=\u20090.07) or on multivariate analysis adjusted for Breslow depth, Clark level, mitotic rate, and ulceration (OR\u2009=\u20091.59, 95% CI: 0.89\u20102.85; <jats:italic>P<\/jats:italic>\u2009=\u20090.12).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For patients with thin melanoma, a positive DM on initial biopsy is not associated with risk of SLN metastasis, so DM positivity should not be considered an indication for SLN staging in an otherwise low\u2010risk patient.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24930","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T15:32:40Z","timestamp":1512055960000},"page":"567-571","source":"Crossref","is-referenced-by-count":18,"title":["Transected thin melanoma: Implications for sentinel lymph node 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