{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:14:01Z","timestamp":1769152441398,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:00:00Z","timestamp":1515369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Giant cell tumors of bone (GCTB) are intermediate and locally aggressive bone tumor. Calcium phosphate cement (CPC) is a bone void filler used in orthopaedic surgery. This study investigated the clinical outcome of GCTB treated with thorough curettage, phenolization, and CPC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated 26 patients with at least 36 months of follow\u2010up. The mean age and follow\u2010up were 37 years (range: 19\u201063) and 87 months (range: 38\u2010169), respectively. Radiological outcomes including consolidation of CPC to the surrounding bone, cortical bone defect remodeling, and clinical outcomes were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The consolidation of CPC to the surrounding bone was excellent in 22 cases (84.6%), good in three (11.5%), and acceptable in one (3.8%). Local recurrence occurred in three cases (11.5%). Pulmonary metastasis occurred in one case (3.8%). Cortical bone defect remodeling appeared in 22 cases (84.6%). The mean Musculoskeletal Tumour Society score was 28.7 (95.7%). Osteoarthritis, chronic synovitis, and fracture were observed in one case each (3.8%), which were managed conservatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Phenolization did not prevent the consolidation of CPC to the bone. CPC provided biological interface and long lasting stability without internal fixation, with comparable complication rates to other published series.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24971","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T09:24:39Z","timestamp":1515576279000},"page":"1232-1238","source":"Crossref","is-referenced-by-count":21,"title":["Mid\u2010 to long\u2010term clinical outcome of giant cell tumor of bone treated with calcium phosphate cement following thorough curettage and phenolization"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4071-5620","authenticated-orcid":false,"given":"Akihiko","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakrit","family":"Suwanpramote","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Maharat Nakhon Ratchasima Hospital Nakhon Ratchasima Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5962-8287","authenticated-orcid":false,"given":"Shinji","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensaku","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"321","volume-title":"World Health Organization Classification of Tumours of Soft Tissue and Bone","author":"Athanasou NA","year":"2013"},{"key":"e_1_2_8_3_1","first-page":"206","article-title":"Curettage of giant cell tumor of bone. 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