{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:59:20Z","timestamp":1773295160286,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Lymphaticovenular anastomosis (LVA) has become one of the useful surgical treatments for compression\u2010refractory lower extremity lymphedema (LEL). It is important to anastomose larger lymphatic vessels with abundant lymph flows in LVA surgery. This study aimed to clarify factors associated with lymphatic vessel diameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred thirty\u2010four LEL patients who underwent pre\u2010operative indocyanine green (ICG) lymphography and LVA from June 2009 to August 2014 in a single institution were included in this retrospective observational study. Clinical, ICG lymphography, and intraoperative findings were collected from medical charts. A lymphatic vessel with external diameters of 0.5\u2009mm or larger was defined as a large lymphatic vessel (LLV). Independent factors associated with LLV were identified using logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine hundred sixty\u2010two lymphatic vessels were identified, among which 438 (45.5%) were LLVs. Independent factors associated with LLV were older age (odds ration [OR], 1.408; 95% confidence interval [CI], 1.026\u20101.931; <jats:italic>P<\/jats:italic>\u2009=\u20090.034), positive history of radiation (OR, 1.634; 95%CI 1.228\u20102.173; <jats:italic>P<\/jats:italic>\u2009=\u20090.001), incision site in the thigh\/lower leg compared with in the groin (OR, 1.617\/1.685; 95%CI 1.076\u20102.432\/1.148\u20102.473; <jats:italic>P<\/jats:italic>\u2009=\u20090.021\/0.008). Inverse associations were observed in S\u2010region\/D\u2010region on ICG lymphography compared with L\u2010region (OR, 0.537\/0.048; 95%CI, 0.397\u20100.726\/0.006\u20100.371; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001\/0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>D\u2010region on ICG lymphography had the lowest OR to find LLV, representing that lymphatic vessels found in D\u2010region on ICG lymphography would be significantly smaller than those in L\u2010region. In LVA surgery, D\u2010region should be avoided.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24974","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T17:14:28Z","timestamp":1516641268000},"page":"1157-1163","source":"Crossref","is-referenced-by-count":51,"title":["Lymphatic vessel diameter in female pelvic cancer\u2010related lower extremity lymphedematous limbs"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9223-5987","authenticated-orcid":false,"given":"Takumi","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery National Center for Global Health and Medicine Tokyo Japan"},{"name":"Department of Plastic and Reconstructive Surgery The University of Tokyo Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsunaga","family":"Narushima","sequence":"additional","affiliation":[{"name":"Department of Plastic and 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