{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:07:30Z","timestamp":1787238450163,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T00:00:00Z","timestamp":1518393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Reconstruction of tongue cancer defects is challenging due to the complex anatomy and physiology of the tongue. Here, we classify patterns of tongue tissue loss and describe a treatment algorithm for achieving good functional and oncologic outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 50 tongue squamous\u2010cell carcinomas surgically treated between January 2010\u2010June 2015. Cancer resection and tongue reconstruction were stratified according to the missing anatomical subunits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A type 1 defect is a unilateral and marginal defect, not crossing the midline, and not extending to the posterior\u2010third of the tongue. Type 2 involves the two\u2010anterior\u2010thirds of the mobile body, not crossing the midline, without posterior\u2010third evolvement. Type 3 involves the two\u2010anterior\u2010thirds of the mobile body of the tongue with contralateral extension. Type 4 extends to the tongue base. Type 5 defect comprises any of the previous defects along with involvement of the floor of the mouth. Type 2 and 3 defects were the most common. Microvascular reconstruction was performed in 23 out of 50 patients. Complications included infection, partial necrosis, dehiscence, and microvascular thrombosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our classification system and treatment algorithm represent a reliable method of addressing management of tongue defects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.24991","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T12:46:39Z","timestamp":1518439599000},"page":"1092-1099","source":"Crossref","is-referenced-by-count":66,"title":["Classification of tongue cancer resection and treatment algorithm"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-3964","authenticated-orcid":false,"given":"Giuditta","family":"Mannelli","sequence":"first","affiliation":[{"name":"Unit of Otorhinolaryngology\u2212Head and Neck Surgery Department of Surgery 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