{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T19:07:41Z","timestamp":1770145661928,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006696","name":"Fondazione Guido Berlucchi","doi-asserted-by":"publisher","award":["Grant from Fondazione Guido Berlucchi (Brescia, It)"],"award-info":[{"award-number":["Grant from Fondazione Guido Berlucchi (Brescia, It)"]}],"id":[{"id":"10.13039\/501100006696","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Data on long\u2010term health\u2010related quality of life (HRQL) after esophagectomy for cancer show contradictory results. The aim was to analyze long\u2010term HRQL at 3 or more years after esophagectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Survivors were identified among patients who had undergone esophagectomy during 2007\u20102013 using the local clinic database. Quality of life was assessed using the European Organization for Research and Treatment of Cancer QLQ\u2010C30 and OG25 questionnaires. Specific aspects were selected a priori and compared with published scores from European healthy subjects (mean difference, MD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010five long\u2010term survivors (median follow\u2010up 4 years) were identified. All functional scales and most symptom scales were clinically similar between EC long\u2010term survivors and European healthy subjects. Survivors reported more problems concerning eating (MD 13.1, 95% C.I. 10.6\u201015.6) and reflux (MD 19.7, 95% C.I. 15.9\u201023.5). HQRL variation from discharge to long term was available in 27 participants who reported improvements in role functioning (MD 40.1, 95%C.I. 24.3\u201056.0) and dysphagia (MD \u221241.9, 95% C.I. \u221251.7 to 32.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term HRQL after esophagectomy is similar between EC survivors and European healthy subjects, despite persisting reflux and eating problems. Further research may focus on improvements of postoperative alimentary habits.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.24995","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T20:22:46Z","timestamp":1517948566000},"page":"970-976","source":"Crossref","is-referenced-by-count":25,"title":["Long\u2010term quality of life after esophagectomy with gastric pull\u2010up"],"prefix":"10.1002","volume":"117","author":[{"given":"Silvia","family":"Mantoan","sequence":"first","affiliation":[{"name":"Surgical Oncology Unit Veneto Institute of Oncology IOV IRCCS Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0831-3971","authenticated-orcid":false,"given":"Francesco","family":"Cavallin","sequence":"additional","affiliation":[{"name":"Surgical Oncology Unit Veneto Institute of Oncology IOV IRCCS Padua 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