{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:28:53Z","timestamp":1761060533290,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Proper staging is critical to the management of pancreatic ductal carcinoma (PDAC). Laparoscopy has been used to stage patients without gross metastatic disease with variable success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to identify the frequency of patients diagnosed by laparoscopy with occult metastatic disease. Also, we looked for variables related to a higher chance of occult metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with PDAC submitted to staging laparoscopy either immediately before pancreatectomy or as a separate procedure between January 2010 and December 2016 were included. None presented gross metastatic disease at initial staging. We used logistic regression to search for variables associated with metastatic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population consisted of 63 patients. Among all patients, nine (16.7%) had occult metastases at laparoscopy. Unresectable tumor (Odds ratio\u2009=\u200918.0, <jats:italic>P<\/jats:italic>\u2009=\u20090.03), increasing tumor size (Odds ratio\u2009=\u20091.36, <jats:italic>P<\/jats:italic>\u2009=\u20090.01), and abdominal pain (Odds ratio\u2009=\u20095.6, <jats:italic>P<\/jats:italic>\u2009=\u20090.04) significantly predicted the risk of occult metastases in univariate analysis. In multivariate analysis, only tumor size predicted the risk of occult metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Laparoscopy remains a valuable tool in PDAC staging. Patients with either large or unresectable tumors, or presenting with abdominal pain present the highest risk for occult intra\u2010abdominal metastases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25024","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T17:49:53Z","timestamp":1520358593000},"page":"819-828","source":"Crossref","is-referenced-by-count":2,"title":["Role of staging laparoscopy in the management of Pancreatic Duct Carcinoma (PDAC): Single\u2010center experience from a tertiary hospital in Brazil"],"prefix":"10.1002","volume":"117","author":[{"given":"Victor Hugo Fonseca","family":"de Jesus","sequence":"first","affiliation":[{"name":"Medical Oncology Department\u2014A.C. 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