{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:31:26Z","timestamp":1761744686874,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T00:00:00Z","timestamp":1521849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/50838\u20105"],"award-info":[{"award-number":["2011\/50838\u20105"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Evaluate radiological characteristics of postpleurodesis pleural space of patients with recurrent malignant pleural effusion(RMPE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective cohort study including patients with RPME treated with bedside pleurodesis. We used CT scans to calculate pleural cavity volume immediately before pleurodesis(iCT) and 30 days after(CT30). Radiological evolution was calculated by the difference between pleural volumes on CT30 and iCT(\u0394volume). We categorized initial pleural volume as small(&lt;500\u2009mL) or large space(\u2265500\u2009mL) and \u0394volume as positive(&gt;254.49\u2009mL), unchanged(\u2265\u2212268.77\u2212\u2264\u2009254.49\u2009mL), or negative(&lt;\u2212268.77\u2009mL). Futhermore, we analyzed clinical effectiveness, pleural elastance, and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 87 patients were analyzed. Pleural volume varied from 35\u20102750\u2009mL in iCT and from 0\u20102995\u2009mL in CT30(<jats:italic>P<\/jats:italic>\u2009=\u20090.753). A total of 54 patients had initial small pleural space(62.06%) and 33 large(37.93%). Clinical failure occurred in 7.4% of small space group and in 24.6% of large(<jats:italic>P<\/jats:italic>\u2009=\u20090.051, OR4.0(CI:1.098\u201014.570)). In small space group, 27.77% evolved with positive, 66.66% with unchanged and 5.55% with negative \u0394volume. In the large space group these numbers were respectively 21.21%, 27.27%, and 51.51%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is significant variability on pleural space volume. However, pleural volume remains unchanged in many cases. Besides that, more than half patients with initial large space coursed with relevant reduction. Finally, patients with initial small space presented a greater chance of clinical success.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25040","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T08:54:47Z","timestamp":1521881687000},"page":"1556-1562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["What happens to the pleural space affected by malignant effusion after bedside pleurodesis?"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0817-8180","authenticated-orcid":false,"given":"Pedro H.X.N","family":"de Araujo","sequence":"first","affiliation":[{"name":"Thoracic Surgery Division Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo M.","family":"Terra","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Division Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago","family":"da Silva Santos","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Division Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo C.","family":"Chate","sequence":"additional","affiliation":[{"name":"Radiology Division Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio F.L.","family":"de Paiva","sequence":"additional","affiliation":[{"name":"Radiology Division Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo M.","family":"P\u00eago\u2010Fernandes","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Division Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2448"},{"key":"e_1_2_8_3_1","first-page":"CD002916","article-title":"Pleurodesis for malignant pleural effusions","volume":"1","author":"Shaw P","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.135.2.7367618"},{"key":"e_1_2_8_5_1","first-page":"777","article-title":"Radiological changes of talc pleurodesis in cases of effusion","volume":"48","author":"Carignan S","year":"1994","journal-title":"Ann 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