{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:26:03Z","timestamp":1788585963341,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Basosquamous carcinoma (BSC) is a rare, biologically aggressive tumor. This cross\u2010sectional study aims to define risk factors for subclinical nodal metastasis in primary BSC, and identify the patients who would benefit from routine sentinel node biopsy (SLNB) as part of the initial management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 142 patients, with histologically proven BSC without palpable lymph nodes, underwent SLNB after the initial excision. Clinicopathological features and demographics were analyzed between the patients with detected micrometastasis (SLNM) and those with negative SLN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 7.7% patients, subcapsular and &lt;0.1\u2009mm SLNM were found. The frequency of SLNM was 0.9%, 11.8%, and 80.0% in patients with maximum lesion diameter\u2009\u2264\u20092\u2009cm, 2.1\u20103.0\u2009cm and &gt;3.0\u2009cm, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and was strongly associated with perineural (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; OR\u2009=\u200926.46, 95% CI\u2009=\u20095.62\u2010124.52) and lymphatic invasion (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; OR\u2009=\u200917.35, 95% CI\u2009=\u20094.44\u201067.91).<\/jats:p><jats:p>Within 18\u201084 months, no recurrence or metastasis were observed in SLNM positive patients. False negative SLNB rate of 15.4% was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cutaneous BSC is associated with early nodal metastatic potential. Tumor size &gt;2\u2009cm, lymphatic and perineural invasion are significant determinants for SLN micrometastasis. In the absence of palpable lymphadenopathy, wide resection and SLNB with long\u2010term follow\u2010up are highly recommended in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25062","type":"journal-article","created":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T14:18:06Z","timestamp":1525184286000},"page":"1752-1758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sentinel lymph node metastasis in primary cutaneous basosquamous carcinoma. A cross\u2010sectional study"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2107-6170","authenticated-orcid":false,"given":"Despoina D.","family":"Kakagia","sequence":"first","affiliation":[{"name":"Department of Plastic Reconstructive Surgery and Burn Unit Athens State Hospital \u201cG. Gennimatas\u201d Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polyxeni","family":"Zapandioti","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive Surgery and Burn Unit Athens State Hospital \u201cG. Gennimatas\u201d Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigoris","family":"Trypsiannis","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics Democritus University in Thrace Alexandroupoolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra N.","family":"Grekou","sequence":"additional","affiliation":[{"name":"\u201cHistodiagnostiki\u201d Histopathology Laboratory Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimosthenis","family":"Tsoutsos","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive Surgery and Burn Unit Athens State Hospital \u201cG. Gennimatas\u201d Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"830e2","article-title":"Basosquamous carcinoma","volume":"29","author":"Bowman PH","year":"2003","journal-title":"Dermatol Surg"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2005.06.007"},{"key":"e_1_2_6_4_1","first-page":"172","article-title":"The relation of rodent ulcer to squamous cell carcinoma of the skin","volume":"19","author":"MacCormac H","year":"1910","journal-title":"Arch Middlesex Hosp"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.09.036"},{"key":"e_1_2_6_6_1","first-page":"9","article-title":"Metatypical basal\u2010cell carcinoma: an analysis in historical perspective","author":"Kelly SC","year":"2003","journal-title":"Dermato Pract Concept"},{"key":"e_1_2_6_7_1","volume-title":"Weedon's Skin Pathology","author":"Weedon D","year":"2010"},{"key":"e_1_2_6_8_1","volume-title":"Lever's histopathology of the skin","author":"Elder DE","year":"2005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.02.051"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00999.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/(SICI)1097-0142(20000315)88:6<1365::AID-CNCR13>3.0.CO;2-Y","article-title":"Basosquamous carcinoma: analysis of prognostic factors influencing recurrence","volume":"88","author":"RC Martin","year":"2000","journal-title":"Cancer"},{"key":"e_1_2_6_12_1","first-page":"293","article-title":"Cutaneous basosquamous carcinoma: review of the literature and report of 35 cases","volume":"95","author":"Borel DM","year":"1973","journal-title":"Arch Pathol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800815)46:4<748::AID-CNCR2820460419>3.0.CO;2-K"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)81069-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-27-65"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2009.05.058"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459987908700405"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2012.1890"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2015.01.007"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2004.01.026"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310460"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32300.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2011.23.S1.S123"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540220042028"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510036457"},{"key":"e_1_2_6_26_1","first-page":"738","article-title":"Patient\u2010related delay in presentation for cutaneous squamous cell carcinoma","volume":"36","author":"Kakagia D","year":"2013","journal-title":"A cross\u2010sectional clinical study. Onkologie"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.65.768.750"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21143"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-999-0012-9"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e3283571089"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2004.05.008"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.25062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T02:00:27Z","timestamp":1694743227000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.25062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/jso.25062"],"URL":"https:\/\/doi.org\/10.1002\/jso.25062","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"2017-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}