{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:12:37Z","timestamp":1789049557024,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T00:00:00Z","timestamp":1525305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Venous patency rates after pancreaticoduodenectomy (PD) with portal vein (PV) resection are not well established, and the oncologic impact of portal vein thrombosis (PVT) is unknown. The primary aim of this study was to determine rates and predictors of PVT after PD with PV resection for pancreatic adenocarcinoma (PDAC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was performed on PDAC patients treated with preoperative therapy and PD with PV resection at a high\u2010volume institution (2008\u201015). Primary outcomes were early and late PVT (\u2264 or &gt;90 days of surgery). Secondary outcomes included major complications and OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients undergoing vein resection (<jats:italic>N<\/jats:italic>\u2009=\u2009120) included 41.7% (<jats:italic>N<\/jats:italic>\u2009=\u200950) primary repair or patch venoplasty, 29.2% (<jats:italic>N<\/jats:italic>\u2009=\u200935) primary anastomosis, and 29.2% (<jats:italic>N\u2009<\/jats:italic>=\u200935) interposition graft. Thirty\u2010four (28.3%) patients developed PVT (early 7.5% [<jats:italic>N<\/jats:italic>\u2009=\u20099]; late 20.8% [<jats:italic>N<\/jats:italic>\u2009=\u200925]). Late PVT was often detected concurrently with local recurrence (76.0%; <jats:italic>N<\/jats:italic>\u2009=\u200919). There was no association of PVT with vascular resection extent or complications (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). On multivariable analysis, PVT was associated with worse OS (HR 2.2 [95% CI 1.34\u20103.5], <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall postoperative patency rates following PV resection PDAC were high. PVT is associated with worse OS, which appears less likely related to technical issues, but rather representative of disease biology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25067","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T23:08:04Z","timestamp":1525388884000},"page":"1648-1654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Vein resection during pancreaticoduodenectomy for pancreatic adenocarcinoma: Patency rates and outcomes associated with thrombosis"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4355-2185","authenticated-orcid":false,"given":"Rebecca A.","family":"Snyder","sequence":"first","affiliation":[{"name":"Department of Surgery University of South Carolina School of Medicine\u2010Greenville Greenville South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura R.","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela M.","family":"Nogueras\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8581-4529","authenticated-orcid":false,"given":"Thomas A.","family":"Aloia","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Nicolas","family":"Vauthey","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason B.","family":"Fleming","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology H. 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