{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:22:59Z","timestamp":1762507379858,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T00:00:00Z","timestamp":1525305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Interleukin\u20106 (IL\u20106) is closely associated with tumor progression. Whether it can predict postoperative prognosis of patients with T2 gallbladder cancer (GBC) remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively collected the medical records of 125 patients with T2 GBC. Then, we analyzed the association between preoperative serum IL\u20106 levels and postoperative survival by multivariate Cox analyses and Kaplan\u2010Meier curves in exploratory subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Predictive effects of serum IL\u20106 levels on overall survival were similar across most of the evaluated subgroups, except in different tumor location subgroups. The independent odds ratio (OR) of serum IL\u20106 levels was 2.57 (95%CI 1.73\u20103.82) in the hepatic side subgroup, while it was 1.15 (95%CI 0.68\u20101.93) in the peritoneal side subgroup (<jats:italic>P<\/jats:italic>\u2009=\u20090.014 for interaction). When we categorized serum IL\u20106 levels by median value (4.2\u2009pg\/mL), the 5\u2010year survival rate of patients with high serum IL\u20106 levels was significantly higher in the hepatic side subgroup (58.5% vs 14.8%, <jats:italic>P\u2009<\/jats:italic>&lt;<jats:italic>\u2009<\/jats:italic>0.001), but no such difference was found in the peritoneal side subgroup (62.2% vs 67.6%, <jats:italic>P\u2009<\/jats:italic>=\u20090.722).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative serum IL\u20106 is significantly associated with prognostic implications in patients with hepatic side T2 GBC, not in those with peritoneal side tumors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25085","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T23:10:37Z","timestamp":1525389037000},"page":"1672-1678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The association between preoperative serum interleukin\u20106 levels and postoperative prognosis in patients with T2 gallbladder cancer"],"prefix":"10.1002","volume":"117","author":[{"given":"Jianfa","family":"Wang","sequence":"first","affiliation":[{"name":"Department of General Surgery Minhang Branch Zhongshan Hospital Fudan University Shanghai P.R. China"},{"name":"Institute of Fudan\u2010MinhangAcademic Healthy System Minhang Hospital Fudan university Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiazhe","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Minhang Branch Zhongshan Hospital Fudan University Shanghai P.R. China"},{"name":"Institute of Fudan\u2010MinhangAcademic Healthy System Minhang Hospital Fudan university Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qimeng","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Minhang Branch Zhongshan Hospital Fudan University Shanghai P.R. China"},{"name":"Institute of Fudan\u2010MinhangAcademic Healthy System Minhang Hospital Fudan university Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Minhang Branch Zhongshan Hospital Fudan University Shanghai P.R. China"},{"name":"Institute of Fudan\u2010MinhangAcademic Healthy System Minhang Hospital Fudan university Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery Minhang Branch Zhongshan Hospital Fudan University Shanghai P.R. China"},{"name":"Institute of Fudan\u2010MinhangAcademic Healthy System Minhang Hospital Fudan university Shanghai P.R. 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