{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T17:13:07Z","timestamp":1781975587309,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T00:00:00Z","timestamp":1526947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine carcinoma of the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe clinical outcome and prognostic factors of MCC patients in two expert\u2010centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with histologically confirmed MCC in 1990\u20102014 were included. Data on patient, tumor characteristics and treatment were retrospectively collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 351 Patients were evaluated, 153 (44%) males, median age 74 years (range 28\u201094). Median follow\u2010up time was 28 months (IQR 13\u201058). Median primary tumor size was 17\u2009mm (range 2\u2010135). At time of diagnosis 112 (32%) patients had lymph node metastases. The cohorts\u2032 5\u2010year overall survival (OS) was 58%. Using a competing risk analysis the 5\u2010year relapse and MCC related death was 42% and 22%. Adjuvant radiation therapy (XRT) was associated with reduced recurrence (SDH 0.54; CI 0.3\u20100.9). Nodal involvement (SDH 2.7; CI 1.1\u20106.6) and the male gender were associated with higher MCC related death (SDH 3.1; CI 1.2\u20107.9)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a large cohort a low MCC related death, in the presence of a low OS was seen. This indicates that a significant number of MCC patients die due to other causes than MCC. Adjuvant XRT was associated with relapse. Male gender and nodal metastasis were associated with MCC related death.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25090","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T02:07:12Z","timestamp":1527041232000},"page":"1768-1775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Merkel cell carcinoma: Clinical outcome and prognostic factors in 351 patients"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0425-306X","authenticated-orcid":false,"given":"Linde M.","family":"van Veenendaal","sequence":"first","affiliation":[{"name":"Departement of Medical Oncology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C. J.","family":"van Akkooi","sequence":"additional","affiliation":[{"name":"Departement of Surgical Oncology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cees","family":"Verhoef","sequence":"additional","affiliation":[{"name":"Departement of Surgical Oncology Erasmus MC Cancer Institute Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk Jan","family":"Gr\u00fcnhagen","sequence":"additional","affiliation":[{"name":"Departement of Surgical Oncology Erasmus MC Cancer Institute Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Martin C.","family":"Klop","sequence":"additional","affiliation":[{"name":"Departement of Head and Neck Surgery and Oncology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlof D.","family":"Valk","sequence":"additional","affiliation":[{"name":"Departement of Endocrine Oncology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot E. T.","family":"Tesselaar","sequence":"additional","affiliation":[{"name":"Departement of Medical Oncology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl050"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01593-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32834fc9fe"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2011.02.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5266-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.02.056"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-001-0204-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.9319"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5293-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.04.042"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.12.2493"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0615-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-016-0409-1"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13698"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.11.002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.06.001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20167"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02108-X"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.329"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31822c5fc1"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01370.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.031"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.04.061"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129476"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9327-y"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.09.036"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23874"},{"key":"e_1_2_9_30_1","unstructured":"PenberthyL. SEER Registries: Population\u2010based Infrastructure to Support Cancer Research. Presented at the 6th Joint Meeting of the Board of Scientific Advisors and the National Cancer Advisory Board 2015; Department of Health and Human Services & Public Health Service & National Institute of Health & National Cancer Institute."},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603702"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30364-3"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw042"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.6.693"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3757-8"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23222"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0134"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000216771.81362.6b"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10880"},{"key":"e_1_2_9_40_1","first-page":"971","article-title":"Evaluation of factors associated with skin self\u2010examination","volume":"8","author":"Oliveria SA","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.5031"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0392"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2014.04.004"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29452"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30364-3"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29452"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0123"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.25090","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.25090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T02:01:43Z","timestamp":1694743303000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.25090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,22]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/jso.25090"],"URL":"https:\/\/doi.org\/10.1002\/jso.25090","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,22]]},"assertion":[{"value":"2017-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}